September 2011

Chelating ability of sulbactomax drug in arsenic intoxication

The aim of this study was to determine the chelating ability of Sulbactomax drug in arsenic pre-exposed rats. 24 rats were divided into I to III groups. Group I was control while Groups II to III were arsenic exposed and arsenic plus Sulbactomax treated group. Arsenic toxicity was induced via intraperitoneally administration of arsenic trioxide (As2O3) 10 mg/kg body weight/day for three weeks. Toxicity...

Author(s): V. K. Dwivedi, A. Arya, H. Gupta, A. Bhatnagar, P. Kumar and M. Chaudhary

September 2011

Nerve growth factor (NGF) combined with oxygen glucose deprivation (OGD) induces neural ischemia tolerance in PC12 cells

Ischemic cerebrovascular disease is a major disease in humans. To better study this disease, a good ischemia model of nerve cells is needed. Nerve growth factor (NGF) could induce PC12 cells to become neurons. Oxygen glucose deprivation (OGD) could lead to hypoxia and neuronal ischemia. In this study, we used NGF and OGD to stimulate PC12 cells and converted them into neurons in order to establish an ischemia model....

Author(s): Chunli Mei, Jinting He, Jing Mang, Guihua Xu, Zhongshu Li, Wenzhao Liang and Zhongxin Xu

September 2011

Kinetic study of different flavonoids as inhibitors of beta-lactamase enzyme

The phenotypic study of the clinical strain Escherichia coli K18 showed that it is resistant to penicillin and amoxicillin-clavulanate, but susceptible to the combination of piperacillin-tazobactam and the cephalosporins 3rd generation and meropenem. The isolated β-lactamase, using ion-exchange chromatography on resin Mono-Q, gave a yield of 56%, a purification factor equal to 5.9, a molecular weight...

Author(s): BOUSSOUALIM, Naoual, MEZIANE-CHERIF, Djalal and BAGHIANI, Abderrahmane