African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 64

The effect of the mixture of garcinia kola and honey on the liver of wistar rats

Avwioro OG
  • Avwioro OG
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar
Ogunbayo TJ
  • Ogunbayo TJ
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar
Ekhueorhan A
  • Ekhueorhan A
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar
Onyije FM
  • Onyije FM
  • Department of Medical Laboratory Science, Faculty of Basic Medical Science, Niger Delta University, Bayelsa State, Nigeria
  • Google Scholar
Adedeji TM
  • Adedeji TM
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar


  •  Received: 01 November 2014
  •  Accepted: 01 December 2014
  •  Published: 31 December 2014

Abstract

Aim: A mixture of honey and Garcinia kola has been used for the treatment of certain dry coughs and diseases. The effect of the recommended dosage of the mixture on the liver was investigated.

Methods: Twenty five Wistar albino rats weighing between 170g and 190g were grouped into 5. There were 5 rats each group. The rats were fed twice daily at 8.00am and 6.00pm with a mixture of G. kola and honey 0.16g/kg + 0.5ml, 0.20g/kg + 0.5ml, 0.24g/kg + 0.5ml, 0.28g/kg + 0.5ml and normal feeds respectively for 14 days. The rats were sacrificed on the 15th day and blood and liver tissues were taken for biochemical analysis and histology respectively.

Results: Aspartate aminotransferase, alanine aminotransferase, bilirubin, alkaline phosphatase and total protein as well as the histology of the liver were not significantly different from the control animals.

Conclusion: Oral intake of one nut G. kola along with 5 ml honey twice daily for 14 days does not have adverse effects on the liver of Wistar rats.

Key words: Medicinal plant, Honey, Garcinia kola, Liver, Biochemistry