Aim: This study was conducted to determine and compare the immunohistochemical expression of p16(INK4a) in cervical dysplasia and carcinoma in Gombe, Nigeria.
Materials: Seventy eight cases of cervical neoplasm; comprising 17 cases of cervical intraepithelial neoplasia (CIN), 53 cases of squamous cell carcinoma (SCC), 6 cases of adenocarcinoma and 2 cases of adenosquamous carcinoma. All samples were stained using p16(INK4a) Rabbit monoclonal anti-CDKN2A/p16(INK4a) antibody.
Results: The p16(INK4a) expression was graded as negative, focal and diffuse positivity. The study showed p16(INK4a) expression in CIN I, CIN II and CIN III as 0%, 80.0% and 83.3% respectively. Majority of SCC (88.7%), adenocarcinoma (83.3%) and adenosquamous carcinoma (100%) showed p16(INK4a) expression.
Conclusion: Immunohistochemical detection of p16(INK4a) can be a useful diagnostic marker for all degrees of cervical dysplasias and carcinomas.
Key words: Dysplasia, Carcinoma, Immunohistochemistry, HPV, p16, Neoplasia,
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