African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 64

Full Length Research Paper

Comparative study of the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera L. on the cerebellar cortex of Artesunate–Amodiaquine treated adult Wistar rats

M. N. Budaye
  • M. N. Budaye
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
  • Google Scholar
S. S. Adebisi
  • S. S. Adebisi
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
  • Google Scholar
A. A. Buraimoh
  • A. A. Buraimoh
  • Department of Human Anatomy, Faculty of Medicine, Kaduna State University, Kaduna, Nigeria.
  • Google Scholar
S. S. Lazarus
  • S. S. Lazarus
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
  • Google Scholar
A. N. Agbon
  • A. N. Agbon
  • Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
  • Google Scholar


  •  Received: 23 April 2018
  •  Accepted: 28 May 2018
  •  Published: 31 July 2018

Abstract

This study was to evaluate the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera on the cerebellar cortex of Artesunate-Amodiaquine (AS–AQ) treated Wistar rats. Thirty-six adult male Wistar rats were randomly divided into nine groups (n=4). Group 1 served as the control; Group 2 received 2.86/8.75 mg/kg AS–AQ. Group 3 received 2.86/8.75 mg/kg AS–AQ + 100 mg/kg ascorbic acid; Groups 4, 5 and 6 received 2.86/8.75 mg/kg AS–AQ + 500 mg/kg aqueous extract of P. dactylifera (AEPD), 2.86/8.75 mg/kg AS–AQ + 1000 mg/kg AEPD and 2.86/8.75 mg/kg AS–AQ + 1500 mg/kg AEPD respectively. Groups 7, 8 and 9 received 2.86/8.75 mg/kg AS–AQ + 500 mg/kg ethanolic extract of P. dactylifera (EEPD), 2.86/8.75 mg/kg AS–AQ + 1000 mg/kg EEPD and 2.86/8.75 mg/kg AS–AQ + 1500 mg/kg EEPD respectively. All administration was orally done, and lasted for 28 days. Evidences of necrosis, chromatolysis and vacuolations were observed in the cerebellar cortex of the AS–AQ treated group. The histoarchitecture of the AEPD and EEPD treatment groups were preserved in a dose-dependent manner, and compared positively to the reference drug ascorbic acid treatment, with the AEPD-treated groups being better preserved. Amelioration of the severity of neurodegeneration by the extracts suggest that the extracts could have exerted their ameliorative effects by antioxidant activities ascribed to the phytochemicals present in the extracts.

Key words: Phoenix dactylifera L. cerebellum, Artesunate-Amodiaquine, Wistar rats.