African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 64

Full Length Research Paper

Some plasma biochemical changes in layers experimentally infected with Salmonella gallinarum

Chiroma Mohammed Adam
  • Chiroma Mohammed Adam
  • Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Borno State, Nigeria.
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Adamu Sani
  • Adamu Sani
  • Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Zaria, Nigeria.
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Gadzama Joseph John
  • Gadzama Joseph John
  • Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Borno State, Nigeria.
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Esievo King Akpofure Nelson
  • Esievo King Akpofure Nelson
  • Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Zaria, Nigeria.
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Abdulsalam Hassan
  • Abdulsalam Hassan
  • Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Borno State, Nigeria.
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Balami Arhyel Gana
  • Balami Arhyel Gana
  • Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Maiduguri, Borno State, Nigeria.
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Enam Samson James
  • Enam Samson James
  • Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Zaria, Nigeria.
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Muhammad Ya’u
  • Muhammad Ya’u
  • Department of Animal Health and Production, Binyaminu Usman Polytechnic Hadejia, Jigawa State.
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Atata Abdulhamid Jamila
  • Atata Abdulhamid Jamila
  • Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ilorin, Kwara State.
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  •  Received: 01 November 2017
  •  Published: 31 December 2017

Abstract

Aim: The study was conducted to investigate some plasma biochemical changes in
layers experimentally infected with Salmonella Gallinarum
Methods: A total of 20 eighteen-week- old ISA Brown layers were used in the experiment. The birds were randomly divided into two groups; infected and control, of 10 birds each. Each bird in the infected group was orally administered 0.5 ml of the inoculum containing 9x108CFU/ml. Similarly, birds in the control group were each administered 0.5 ml normal saline only. All the experimental birds were closely monitored for clinical signs of fowl typhoid. Blood samples were collected from each group at day zero (Day 0), 2, 4, 7, 14, 21, 28, 35 and 42, post-infection and used for determination of plasma biochemical parameters.
Results: By day seven post infection, all birds in the infected group showed clinical signs typical of fowl typhoid; weakness, ruffled feathers, huddling together, somnolence, greenish-yellow diarrhea, weight loss, drop in egg production, decrease in feed and water consumption and mortality rate (50%). There were, however, marked increase in the plasma activities of aspartate aminotransferase, alanine aminotransferase,  alkaline  phosphatase  and  the  level  of  urea  and  significant
hypoprotinemia.
Conclusion: The experimental Salmonella Gallinarum infection induced alteration in the liver and kidney functions.
 
Key Words: Salmonella Gallinarum, Typhoid, ISA brown layers.