African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 65

The effect of oral administration of the mixture of honey and garcinia kola on the kidney of wistar rats

Avwioro OG
  • Avwioro OG
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar
Demehin AO
  • Demehin AO
  • Faculty of Science, Delta State University, Abraka, Nigeria
  • Google Scholar
Onyije FM
  • Onyije FM
  • Department of Medical Laboratory Science, Faculty of Basic Medical Science, Niger Delta University, Bayelsa State, Nigeria
  • Google Scholar
Bini N
  • Bini N
  • Department of Chemical Pathology, Health Management Board, Delta State, Nigeria
  • Google Scholar
Oladele AA
  • Oladele AA
  • Department of Histopathology, Afe Babalola University, Ado Ekiti, Nigeria
  • Google Scholar
Umukoro S
  • Umukoro S
  • Department of Community Medicine, Faculty of Clinical Science, Delta State University, Abraka, Nigeria
  • Google Scholar


  •  Received: 01 November 2014
  •  Accepted: 01 December 2014
  •  Published: 31 December 2014

Abstract

Aim: Honey and Garcinia kola have long been used separately by the traditional medical practitioners as remedies for cough and other ailments. Recently, a combination of both as a remedy for cough is common. This work was intended to see the effect of this synergy on the kidney.

Methods: Twenty five Wistar albino rats weighing 180±10g were grouped into 5 (A, B, C, D, E) of 5 rats each. They were fed twice daily for 14 days with a mixture of G. kola and honey: 0.16g/kg + 0.5ml, 0.20g/kg + 0.5ml, 0.24g/kg + 0.5ml, 0.28g/kg + 0.5ml and normal feeds respectively. The rats were sacrificed on the 15th day and blood and kidneys were taken for biochemistry and histology respectively.

Results: Sodium, potassium, chloride, bicarbonate, urea, creatinine, as well as the histology of the kidney of the test rats were not significantly different from the control rats.

Conclusion: Oral intake of one nut Garcinia kola along with about 5 ml honey  twice daily for 14 days has no adverse effect on the kidney.

Key words: Honey, Garcinia kola, Liver, Medicinal plant