African Journal of
Environmental Science and Technology

  • Abbreviation: Afr. J. Environ. Sci. Technol.
  • Language: English
  • ISSN: 1996-0786
  • DOI: 10.5897/AJEST
  • Start Year: 2007
  • Published Articles: 1055

Full Length Research Paper

Impairment in biochemical indices in sprayers exposed to commonly used organophosphorus and pyrethroids: A case study

Padmaja R. Jonnalagadda1*, A. Y. E. Prasad1, U. V. R. Vijaya Sarathi2,  G. Manohar3 and K. Venkaiah4
  1Food and Drug Toxicology Research Centre (FDTRC), National Institute of Nutrition, Indian Council of Medical Research, Department of Health Research,  Hyderabad-500007, (A.P), India. 2National Centre for Mass Spectrometry, Indian Institute of Chemical Technology [IICT], Tarnaka, Hyderabad-607, India. 3Field Division, National Institute of Nutrition, Indian Council of Medical Research, Department of Health Research, Hyderabad-500007, (A.P), India. 4Department of Biostatistics, National Institute of Nutrition, Indian Council of Medical Research, Department of Health Research, Hyderabad-500007, (A.P), India.
Email: [email protected]

  •  Accepted: 01 August 2013
  •  Published: 31 August 2013

Abstract

 

      This study was carried out to evaluate the effect of spraying organophosphate, carbamate and synthetic pyrethroid pesticides on biochemical parameters viz., red blood cell (RBC) acetylcholine esterase (AchE) and plasma butyrylcholinesterase (BChE) activities, oxidative stress parameters viz.,  plasma T-BARs, catalase activity and antioxidant levels such as reduced glutathione, and α-tocopherol and pesticide residues (analysed using the GC/LC-MS/MS) in sprayers cultivating cotton, chilly and paddy crops in Guntur district for a period of >10 years. The study population included sprayers (120) with a mean age of 37.8 ± 10.8 years and controls (60) with a mean age of 37.3 ± 12.2 years. A significant difference was observed for AchE, BChE activities, thiobarbituric acid reactive substances (TBARs), catalase activity, reduced glutathione and the concentration of pesticide residues in the sprayers cultivating different crops for a period of >10 years as compared to the controls. However, there is no such significant difference observed for α-tocopherol.

 

 Key words: Pesticide residues, chronic exposure, biochemical indices, sprayers running head, biochemical indices, pesticide residues in sprayers