In this article, the mathematical model used originally proposed by Bruce and co-workers was reviewed and extended. By assuming spherical symmetry of tumour, there were mathematical expressions in the form of partial differential equations along with some suitable conditions for density of proliferating tumor cells, quiescent tumor cells, surrounding tissue macromolecule (MM) and concentration of matrix degradative enzyme (MDE) and oxygen.
Key words: Mathematical modeling, tumour invasion, partial differential equations.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0