African Journal of
Medical and Health Sciences

OFFICIAL PUBLICATION OF THE FEDERAL TEACHING HOSPITAL, ABAKALIKI, NIGERIA
  • Abbreviation: Afr. J. Med. Health Sci.
  • Language: English
  • ISSN: 2384-5589
  • DOI: 10.5897/AJMHS
  • Start Year: 2017
  • Published Articles: 39

Full Length Research Paper

The evaluation of Cleopatra I score for predicting preterm birth in subjects with threatened preterm labour

Varsha Maran
  • Varsha Maran
  • Obstetrics and Gynaecology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
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Nandita Maitra
  • Nandita Maitra
  • Department of Obstetrics and Gynaecology, SSGH, Vadodara, India.
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Tosha Sheth
  • Tosha Sheth
  • Department of Obstetrics and Gynaecology, SSGH, Vadodara, India.
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Palak Vaishnav
  • Palak Vaishnav
  • Department of Obstetrics and Gynaecology, SSGH, Vadodara, India.
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Niyati Takhatsinh Parmar
  • Niyati Takhatsinh Parmar
  • Department of Preventive and Social Medicine, SSGH, Vadodara, India.
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  •  Received: 13 November 2019
  •  Accepted: 21 October 2020
  •  Published: 30 November 2020

Abstract

This work aims to evaluate the Cleopatra I model for the prediction of spontaneous preterm birth (PTB) in subjects having threatened preterm labour. This is a hospital-based prospective observational study done over a period of one year. A total of one hundred and eleven (111) subjects enrolled in the study. Their demographic factors and previous obstetric history were recorded. A cervical length with a cut-off of 25 mm measured by a transvaginal ultrasound was used to evaluate the primary endpoint of the study. Grossly, the preterm delivery rate was 70% in subjects with short cervical length. Funnelling of cervix was associated with 61.1% of those subjects who delivered preterm. Cervical length with a cut-off of ≤2.5 cm showed a sensitivity of 82.1% and a specificity of 37.5% in predicting preterm delivery. In our study, cervical length and funnelling were found to be significantly associated with the outcome of preterm delivery as per the Bivariate analysis. However, on applying logistic regression analysis, funnelling was found to be the only significant association in the prediction of preterm delivery. Thus, the findings of our study could not endorse the observations of the CLEOPATRA I model.

Key words: Risk assessment, premature birth, cervical length measurement.