African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 4919

Full Length Research Paper

Antimicrobial effect of amphotericin B electronically-activated water against Candida albicans

J. Antonio Heredia-Rojas1, Ricardo Gomez-Flores2, Abraham O. Rodríguez-de la Fuente1*, Enriqueta Monreal-Cuevas2, Antonio Cayetano Torres-Flores3, Laura E. Rodríguez-Flores4, Michaela Beltcheva5 and Antonio Cayetano Torres-Pantoja3  
1Universidad Autónoma de Nuevo León, UANL. Facultad de Ciencias Biológicas,   Av. Universidad S/N. Ciudad Universitaria, San Nicolás de los Garza Nuevo León, C.P. 66451 México. 2Universidad Autónoma de Nuevo León,UANL. Facultad de Ciencias Biológicas, Departamento de Ciencias Exactas y Desarrollo Humano, Av. Universidad S/N, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, C.P. 66451 México. 3Universidad Autónoma de Nuevo León,UANL. Facultad de Ciencias Biológicas, Departamento de Microbiología e Inmunología, Av. Universidad S/N, Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, C.P. 66451 México. 4Universidad Autónoma de Nuevo León UANL, Facultad de Medicina, Av. Francisco I. Madero pte. S/N, Col. Mitras Centro, Monterrey, Nuevo León, C.P. 66460 México. 5Bulgarian Academy of Sciences, Institute of Biodiversity and Ecosystem Research, 1, Tzar Osvoboditel Blvd., 1000 Sofia, Bulgaria.  
Email: [email protected]

  •  Accepted: 22 March 2012
  •  Published: 23 April 2012

Abstract

The activation of water by physical means stimulates a new scientific approach to microbiology, in particular, antimicrobial methods. However, many of these methods are unproven or have not been properly tested. Since the 1980s, a promising procedure known as biophysical-information therapy or bioresonance therapy (BRT) has emerged as an alternative method against microbial diseases, but it has not yet been properly evaluated. It was demonstrated that by transferring amphotericin B (125 µg·ml-1)information to water samples by an electronic amplifier (BRT device), the growth of cultured Candida albicans was significantly (P<0.05) inhibited (46% growth inhibition), compared with those cultures treated with sham electro-activated water samples (0% growth inhibition), and a positive control of amphotericin B (125 µg·ml-1; 80% growth inhibition). Evidence for a measurable biological effect by electro-activated water samples that somehow acquires, or at least mimics, the antifungal property of amphotericin B has been demonstrated in the present study. More studies, however, are necessary to elucidate the mechanism by which such electro-activated water resembles the activity of an antimicrobial agent.

 

Key words: Antimicrobial effect, activated water, bioresonance, amphotericin B, growth inhibition, Candida albicans.

 

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