African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5136

Full Length Research Paper

Atypical manifestation in infection by methicillin-resistant Staphylococcus aureus carrier SCCmec IV and Panton-Valentine Leukocidin-producer in experimental sepsis model

Giorgio Silva-Santana*
  • Giorgio Silva-Santana*
  • Pathology Department, School of Medicine, Fluminense Federal University, Rio de Janeiro, Brazil.
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Katia C. Lenzi-Almeida
  • Katia C. Lenzi-Almeida
  • Pathology Department, School of Medicine, Fluminense Federal University, Rio de Janeiro, Brazil.
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Vania G. S. Lopes
  • Vania G. S. Lopes
  • Pathology Department, School of Medicine, Fluminense Federal University, Rio de Janeiro, Brazil.
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Fabio Aguiar-Alves
  • Fabio Aguiar-Alves
  • Pathology Department, School of Medicine, Fluminense Federal University, Rio de Janeiro, Brazil.
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  •  Received: 16 March 2017
  •  Accepted: 21 April 2017
  •  Published: 14 May 2017

Abstract

Staphylococcus aureus is considered an infectious agent of great clinical importance, responsible for many different types of infection. Strains of methicillin-resistant Staphylococcus aureus (MRSA), Panton-Valentine leukocidin producers, are considered more invasive, presenting clinical sequelae related to abscesses and infection in skin and soft tissues. The use of invasive techniques in hospital environment, such as the introduction of intravascular catheter in immunocompromised patients, has contributed to this microorganism spreading through the bloodstream, causing bacteremia, necrotizing pneumonia and increasing the number of septic patients in intensive care units with high mortality. In this report, atypical infections in Swiss mice using experimental model of sepsis was presented.

Key words: methicillin-resistant Staphylococcus aureus (MRSA), mice infection, Panton-Valentine Leukocidin.