African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5238

Full Length Research Paper

Resistance profile of urine isolate enterobacteral strains at Donka University teaching hospital in Conakry, Guinea

Djiba KABA
  • Djiba KABA
  • Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée.
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Ousmane NIABALY
  • Ousmane NIABALY
  • Laboratoire de Biologie Moléculaire Nestor BANGOURA/Helene LABROUSSE, Hôpital de jour Donka, CHU Donka, Conakry, Guinée.
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Issiaga DIALLO
  • Issiaga DIALLO
  • Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée.
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Ibrahima Sory Nana SYLLA
  • Ibrahima Sory Nana SYLLA
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Castro G. HOUNMENO
  • Castro G. HOUNMENO
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Kadio Jean-Jacques Olivier KADIO
  • Kadio Jean-Jacques Olivier KADIO
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Aly Badara TOURE
  • Aly Badara TOURE
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Boubacar SALL
  • Boubacar SALL
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Emile BONGONO
  • Emile BONGONO
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Lancei KABA
  • Lancei KABA
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Alpha Ousmane BARRY
  • Alpha Ousmane BARRY
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Maladho DIABY
  • Maladho DIABY
  • Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Conakry, Guinée.
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Thomas BALAMOU
  • Thomas BALAMOU
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Pascal KOIVOGUI
  • Pascal KOIVOGUI
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Ouo-Ouo Yaramon KOLIE
  • Ouo-Ouo Yaramon KOLIE
  • Service de Laboratoire de Biologie Médicale, Centre Hospitalo-Universitaire de Donka, Conakry, Guinée.
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Mariama Sadjo DIALLO
  • Mariama Sadjo DIALLO
  • Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée.
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Mohamed CISSE
  • Mohamed CISSE
  • Faculté des Sciences et Techniques de la Santé, Université Gamal Abdel Nasser de Conakry, Guinée.
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  •  Received: 24 February 2024
  •  Accepted: 09 April 2024
  •  Published: 30 April 2024

Abstract

The objective of this study was to describe the resistance profile of enterobacterals isolated from urine samples at the laboratory of Donka National Hospital. Urine samples were collected from both outpatients and hospitalized patients. Cultures were performed using standard techniques, strains were identified using the API 20E kit, and antibiotic susceptibility testing was carried out using the ATB™ UR EU (08) kit. The results were interpreted according to the recommendations of the Antibiogram Committee of the French Society of Microbiology (CASFM v1 2023). Out of a total of 520 urine samples analyzed, 111 were positive for enterobacteral strains. Among them, 75 (67.57%) were of community origin. Escherichia coli was the most represented species (n=61, 55%), followed by Klebsiella pneumoniae (n=24, 22%). The resistance of E. coli strains to third generation cephalosporins (TGC) varied from 5.41% (n=6) to 25.23% (n=28) in the community and from 13 to 38% in the hospital. The profile for carbapenems was categorized as "susceptible to high dosage (SHP)," accounting for 16.22% (n=18). This study provided insight into the resistance profile to antibiotics used in urinary tract infections. The increasing resistance to carbapenems poses a threat to the management of strains producing extended-spectrum beta-lactamases (ESBL). It would be important to strengthen resistance surveillance in this context.

 

Key words: Enterobacteral, urinary tract infection, resistance, community, hospital, Guinea.