African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5238

Full Length Research Paper

Anti-candida and anti-enzyme activity and cytotoxicity of 2-phenyl-4H-chromen-4-one

Simone Gomes Dias de Oliveira*
  • Simone Gomes Dias de Oliveira*
  • Department of Dental Materials, School of Dentistry, Federal University of Vales do Jequitinhonha and Mucuri. Diamantina, MG, Brazil.
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Rafael Guerra Lund
  • Rafael Guerra Lund
  • Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil.
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Rodrigo Varella de Carvalho
  • Rodrigo Varella de Carvalho
  • Department of Restorative Dentistry, School of Dentistry, Meridional Faculty (IMED), Passo Fundo, Brazil.
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Claudio Martin Pereira de Pereira
  • Claudio Martin Pereira de Pereira
  • Centre for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas (UFPel), Pelotas, RS, Brazil.
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Evandro Piva
  • Evandro Piva
  • Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil.
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  •  Received: 15 June 2015
  •  Accepted: 31 August 2015
  •  Published: 21 February 2016

Abstract

This study determined the fungicidal concentration (MFC), anti-enzymatic (production of proteinases and phospholipase), and cytotoxic activities of 2-phenyl-4H-chromen-4-one against different strains of Candida sp. The results were: MIC> 62.5 µg\ml and MFC>250 µg\ml for C. albicans; MIC/MFC = 31.25 µg\ml for C. parapsilosis; MIC/MFC= 62.5 µg/ml for C. famata; MIC/CFM =125 µg\ml for C. glabrata and MIC = 15.62 µg\ml for C. lipolytica. Values ​​for phospholipase and proteinase before and after exposure of yeast to the compound had no statistical differences. For the cytotoxicity test, there were no statistical differences between the tested and control groups. Data from this study provide evidence that 2-phenyl-4H-chromen-4-one could be an alternative source for the treatment of fungal infections caused by Candida. 
 
Key words:  Candida albicans, antifungal activity, antifungal agents, anti-enzyme activity, flavone.

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