African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5056

Full Length Research Paper

Elevated antibody titer against Borrelia burgdorferi in new case of multiple sclerosis patients

  Mohsen Khaki1, Ehsanollah Ghaznavi-Rad1, Ali Ghazavi1, Keyvan Ghasami2 and Ghasem Mosayeb3*
  1Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. 2Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. 3Department of Immunology and Microbiology, Molecular and Medicine Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Email: [email protected]

  •  Accepted: 27 October 2011
  •  Published: 16 December 2011

Abstract

 

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects central nervous system (CNS). The etiology of MS is unknown, but it likely involves a combination of genetic, non-genetic and environmental factors such as microbial agents. In this descriptive case- control study, 61 new cases of MS patients and 60 healthy controls were studied for IgM and IgG antibody titer to Borrelia burgdorferi. The samples were tested for the presence of specific antibodies by ELISA method. The data were analyzed using descriptive statistics. The results showed that specific IgM antibody titer against B. burgdorferi were significantly higher in patient group than control (OR=4.323, 95% CI=1-6.4, p=0.001). Our results confirm the association between B. burgdorferi and MS in Iranian patients.     

 

Key words: Antibody, Borrelia burgdorferi, multiple sclerosis.