African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5124

Full Length Research Paper

Antidiabetic effect of camel milk on alloxan-induced diabetic dogs

A. Sboui1,3*, T. Khorchani1, A. Agrebi3, M. Djegham2, M. Mokni4 and O. Belhadj3
  1Livestock and Wildlife Laboratory, Arid Land Institute, Medenine, Tunisia. 2Veterinary School, Laboratory of Physiology and Therapeutic, Sidi Thabet, Tunisia. 3College of Science, Biochemistry and Technobiology Laboratory, Tunis, Tunisia. 4Farhat Hached Hospital, Anatomy –Pathology Laboratory, Sousse, Tunisia.
Email: [email protected]

  •  Accepted: 08 March 2012
  •  Published: 16 May 2012

Abstract

 

This research was conducted to evaluate the antidiabetic effect of camel milk in alloxan-induced-diabetic dogs. Diabetes was induced by intravenous injection of alloxan monohydrate (65 mg/kg bodyweight). The effects of camel milk on diabetic dogs were investigated by observing changes in the glycometabolic index (fasting blood glucose,intravenous glucose tolerance test (IGTT)) test, the lipometabolic index (triglyceride, cholesterol), total proteins and in the degree of injury of β-cells in the pancreatic islets. A significant decrease in fasting plasma glucose, cholesterol and total proteins in blood sample and an improvement on the animal clinical state (increase of body weight, normal activity) was observed. Camel milk also induces renewal of pancreatic β-cells. A comparison was made between the effect of camel milk and cow milk. Treatment with cow milk does not have any benefit effect on alloxan-induced diabetic dogs.

 

Key words: Alloxan, diabetes, dogs, antidiabetic effect, camel milk, β-cells.