African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 4983

Full Length Research Paper

Prevalence of urinary tract infection and antibiotic resistance pattern in pregnant women, Najran region, Saudi Arabia

Ali Mohamed Alshabi
  • Ali Mohamed Alshabi
  • Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
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Majed Saeed Alshahrani
  • Majed Saeed Alshahrani
  • Department of Obstetics and Gyneocology, Faculty of Medicine, Najran University, Najran, Saudi Arabia.
  • Google Scholar
Saad Ahmed Alkahtani
  • Saad Ahmed Alkahtani
  • Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
  • Google Scholar
Mohammad Shabib Akhtar
  • Mohammad Shabib Akhtar
  • Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
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  •  Received: 25 February 2019
  •  Accepted: 05 August 2019
  •  Published: 31 August 2019

Abstract

Urinary Tract Infection (UTI) is one of the commonest infectious disease in pregnancy, and in pregnancy we have very limited number of antibiotics to treat the UTI.  This study was conducted on 151 patients who attended the gynecology clinic during the study period. Nineteen UTI proven cases of UTI were studied for prevalence of microorganism and sensitivity pattern against different antibiotics. Among the bacteria isolated, Escherichia coli (73.68%) and Staphylococcus aureus (10.52%) were the most prevalent Gram negative and Gram positive bacteria respectively. To know the resistance pattern of microorganism we used commercially available discs of different antibiotics. Gram negative bacteria showed more resistance as compared to Gram positive one. It is observed that the most effective antibiotic for Gram negative isolates is Ceftriaxone (87.5%), followed by Amoxicillin + Clavulanic acid (81.25%), Amikacin (75%), Cefuroxime (75%), Cefixime (68.75%) and Mezlocillin (62.5%). For the Gram positive bacteria, Ceftriaxone, Amikacin and Amoxicillin + Clavulanic acid were the most effective antimicrobials (100%). Multidrug resistance Gram negative bacteria were also tested for Extended-spectrum Beta Lactamase (ESBL), 35.71% of E. coli isolates were ESBL producer.

 

Key words: Urinary tract infection, pregnancy, drug resistance, uropathogens, extended spectrum β-lactamase.