African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5044

Article in Press

Production of bioactive compounds by Streptomyces spp. MPO-4 isolated from Amazonian soil with antifungal activity against filamentous fungi and yeasts

Silvia Katrine Silva Escher, Adrielle Leal Dias, José Jeosafá Vieira de Sousa Júnior, Alexandre Escher Boger2, Denise Castro Lustosa2, Sara Freitas de Sousa2, Juliane Karine Ishida, Tsai Siu Mui, Janete Magali de Araújo and Elba Lúcia Cavalcante de Amorim

  •  Received: 17 July 2015
  •  Accepted: 08 April 2016
This study evaluated the antifungal potential of Streptomyces species MPO-4 isolated from the rhizosphere soil de Aniba parviflora Syn fragans (Macacaporanga) by Agar block technique. Secondary metabolites were obtained in the fermentation broth followed by solvent extraction with ethyl acetate, for further evaluation of the minimum inhibitory concentration (MIC) of the crude extract against Postia placenta, Rhizoctonia solani, and the yeasts Candida albicans and Candida krusei. The Streptomyces spp. MPO-4 was active against R. solani, C. albicans and C. krusei. Antifungal metabolites were produced from the fermentation 24 h for C. albicans and after 48 h for C. krusei and R. solani. The minimum fungicidal concentration for C. krusei is 2000 μg/ml for C. albicans is 1500 and 1200 μg/ml for R. solani. This study revealed the production of bioactive compounds by Streptomyces spp. MPO-4 with antifungal activity against filamentous fungi and yeasts of clinical and environmental interest.

Keywords: Antagonism, Streptomyces species, biological products, Candida albicans, Candida krusei.