African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Adsorption kinetics of 2-chloroacétophénone and 4-bromoacétophénone thiosemicarbazone on Oueme Valley clays (R. Benin)

Tadjou DO REGO
  • Tadjou DO REGO
  • Laboratoire National de Pharmacognosie, Centre Beninois de la Recherche Scientifique et Technique (CBRST), BP 06 Oganla, Porto-Novo, Benin
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Serge Fredys Rodrigue O. SENOU
  • Serge Fredys Rodrigue O. SENOU
  • Laboratoire National de Pharmacognosie, Centre Beninois de la Recherche Scientifique et Technique (CBRST), BP 06 Oganla, Porto-Novo, Benin
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Fidèl DIMON
  • Fidèl DIMON
  • Laboratory of Physical Chemistry, University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), Cotonou, Benin
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Salome KPOVIESSI
  • Salome KPOVIESSI
  • Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi, Faculty of Sciences and Technics (FAST),BP: 4521 Cotonou, Benin
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Alban HOUNGBEME
  • Alban HOUNGBEME
  • Laboratoire National de Pharmacognosie, Centre Beninois de la Recherche Scientifique et Technique (CBRST), BP 06 Oganla, Porto-Novo, Benin
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Coffi AZANDEGBE ENI
  • Coffi AZANDEGBE ENI
  • Laboratory of Physical Chemistry, University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), Cotonou, Benin
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Georges C. ACCROMBESSI
  • Georges C. ACCROMBESSI
  • Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi, Faculty of Sciences and Technics (FAST),BP: 4521 Cotonou, Benin
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Jacques POUPAERT
  • Jacques POUPAERT
  • Louvain Drug Research Institute (LDRI), School of Pharmacy, Université catholique de Louvain, B1 7203 Avenue Emmanuel Mounier 72, B-1200 Brussels, Belgium
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Fernand A. GBAGUIDI
  • Fernand A. GBAGUIDI
  • Laboratoire National de Pharmacognosie, Centre Beninois de la Recherche Scientifique et Technique (CBRST), BP 06 Oganla, Porto-Novo, Benin
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  •  Received: 21 November 2013
  •  Accepted: 03 February 2014
  •  Published: 27 March 2014

Abstract

2-chloroacetophenone-thiosemicarbazone and 4-bromoacétophénone-thiosemicarbazone are compounds endowed with numerous pharmacological properties.  In order to produce therapeutic agents using clay as excipient, this paper deals with the absorption kinetics of a clay originating from Oueme valley in Benin. A prospection in this area gave rise to the collection of 4 samples classified according to their color (yellow, white, black, and red). Toxicity studies performed on larvae gave no evidence of toxicity.  These clays are highly hydrophilic and can accept a high load of organic material. The white clay, which is the least acidic, shows the best adsorption capacity. Additional experiments were carried out with this clay in ethanol. Best adsorption was obtained after 2 h. Absorption isotherms indicate low affinity between the clay and the thiosemicarbazones and can be modelized using Langmuir and Freundlich’s models.

 

Key words: Clay, thiosemicarbazones, kinetic, absorption, larval toxicity, desorption.