2-chloroacetophenone-thiosemicarbazone and 4-bromoacétophénone-thiosemicarbazone are compounds endowed with numerous pharmacological properties. In order to produce therapeutic agents using clay as excipient, this paper deals with the absorption kinetics of a clay originating from Oueme valley in Benin. A prospection in this area gave rise to the collection of 4 samples classified according to their color (yellow, white, black, and red). Toxicity studies performed on larvae gave no evidence of toxicity. These clays are highly hydrophilic and can accept a high load of organic material. The white clay, which is the least acidic, shows the best adsorption capacity. Additional experiments were carried out with this clay in ethanol. Best adsorption was obtained after 2 h. Absorption isotherms indicate low affinity between the clay and the thiosemicarbazones and can be modelized using Langmuir and Freundlich’s models.
Key words: Clay, thiosemicarbazones, kinetic, absorption, larval toxicity, desorption.
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