African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Synthesis and antibacterial activity of metal complexes of barbituric acid

Ikotun A. A.1*, Ojo Y.1, Obafemi C. A.2 and Egharevba G. O2
1Department of Chemistry and Biochemistry, Bowen University, Iwo. 2Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
Email: [email protected]

  •  Accepted: 30 September 2010
  •  Published: 31 May 2011


Cobalt (II), copper (II), iron (III), manganese (II) and nickel (II) complexes of barbituric acid were synthesized and characterized by infrared and ultraviolet spectroscopy. The ligand and the complexes have been screened for in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria (Bacillus authracis, Bacillus cereus, Bacillus stearothemophilus, Bacilis subtilis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Pseudomonas fluorescens, Staphylococcus aureus, Streptococcus faecalis). Cobalt (II) complex displayed a better antibacterial activity than the ligand, showing a broad-spectrum activity against all the six Gram-positive and four Gram-negative bacterial strains, while the other complexes showed only selective activity against the organisms in a manner similar to the starting ligand.


Key words: Antibacterial activity, barbituric acid, complexes, ligand.