African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 354

Short Communication

Synthesis of trans-3,4-dibenzyl-2-oxo-tetrahydrofuran

Jack I. R. and Orubite K. O.*  
Department of Chemistry, Rivers State University of Science and Technology, P. M. B. 5080, Port Harcourt, Nigeria.
Email: [email protected]

  •  Accepted: 07 February 2012
  •  Published: 30 March 2012


Trans-3,4-dibenzyl-2-oxo-tetrahydrofuran (6) a substituted tetrahydrofuranoid lignan was synthesized in 70% yield via the Stobbe condensation between (1) benzaldehyde  and (2) diethyl succinate. The structure was confirmed by the spectral data such as infra-red, proton magnetic resonance and mass spectrum. It has two similar but non equivalent aromatic groups which appeared at δ: 6.48 - 6.76 and 7.06 - 7.25 as multiplets.


Key words: Lignans, tetrahydrofuranoid, Stobbe.