Trans-3,4-dibenzyl-2-oxo-tetrahydrofuran (6) a substituted tetrahydrofuranoid lignan was synthesized in 70% yield via the Stobbe condensation between (1) benzaldehyde and (2) diethyl succinate. The structure was confirmed by the spectral data such as infra-red, proton magnetic resonance and mass spectrum. It has two similar but non equivalent aromatic groups which appeared at δ: 6.48 - 6.76 and 7.06 - 7.25 as multiplets.
Key words: Lignans, tetrahydrofuranoid, Stobbe.
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0