Abstract

A kinetics study of fibrinogen adsorbed on titanium has been investigated by means of spectrophotometer of the type developed for micro-enzyme linked immune-sorbent assay determination. Implants invoke inflammatory responses from the body and an attempt to alleviate the problem caused by the adsorption of protein on artificial implants mostly used in the medical, informed this study. The experimental isotherm data were analysed using the Langmuir equation and the amount of fibrinogen adsorbed increase in contact time and reached close to saturation after 120 min for the initial protein concentration 0.1, 0.2 0.4 and 0.6 mg/ml used in this study. The adsorption process was found to be of first order with respect to the bulk concentration, and in the transient region, the adsorption process is independent of the concentration of protein in the bulk and the actual rate constants for each fibrinogen concentration investigated are, 0.01706, 0.01856, 0.01840 and 0.01841 cm/s.

Key words: Titanium, fibrinogen, implants, kinetics rate, adsorption.