African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 357

Full Length Research Paper

Toxicity study of ethanol root extract of Terminalia macroptera Guill. & Perr. (Combretaceae) and assessment of some heavy metals

Y. Yakubu
  • Y. Yakubu
  • Department of Chemistry, Faculty of Science, Kaduna State University, Kaduna State, Nigeria.
  • Google Scholar
O. A. Adoum
  • O. A. Adoum
  • Department of Pure and Industrial Chemistry, Faculty of Science, Bayero University, Kano, Kano State, Nigeria.
  • Google Scholar
A. M. Wudil
  • A. M. Wudil
  • Department of Biochemistry, Faculty of Science, Bayero University, Kano, Kano State, Nigeria.
  • Google Scholar
Z. Ladan
  • Z. Ladan
  • Department of Chemistry, Faculty of Science, Kaduna State University, Kaduna State, Nigeria.
  • Google Scholar


  •  Received: 03 August 2015
  •  Accepted: 28 September 2015
  •  Published: 30 September 2015

References

Adal A, Wiener SW (2013). Medscape. Heavy Metal Toxicity. http://emedicine.medscape.com/article/814960-overview. Accessed 10/8/2013.
 
ATSDR (2004). Case Studies in Environmental Medicine. pp. 1–42. Available online athttp://www.atsdr.cdc.gov/csem/arsenic /docs/arsenic.pdf
 
ATSDR (2011). Detailed data table for the 2011 priority List of hazardous substances pp. 1–20. Available online at http://www.atsdr.cdc.gov/spl/resources/ATSDR_2011_SPL_Detailed_Data_Table.pdf
 
ATSDR (2008a). ToxGuide for Lead. pp. 1–2. Available online at http://www.atsdr.cdc.gov/toxguides/toxguide-13.pdf
 
ATSDR (2007a). Toxicological profile for arsenic. pp. 1–559. Available online at http://www.atsdr.cdc.gov/toxprofiles/tp2.pdf
 
ATSDR (2007b). Toxicological Profile For Lead. pp. 1–582. Available online at http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf
 
Galanis A, Karapetsas A, Sandaltzopoulos R (2009). Metal-induced carcinogenesis, oxidative stress and hypoxia signalling. Mutat. Res. 674(1-2):31–35.
Crossref
 
Jang DH, Hoffman RS (2011). Heavy metal chelation in neurotoxic exposures. Neurol. Clin. 29(3):607–622.
Crossref
 
Lorke D (1983). A new approach to practical acute toxicity testing. Arch. Toxicol. 53:275-287.
Crossref
 
Orloff K, Mistry K, Metcalf S (2009). Biomonitoring for environmental exposures to arsenic. J. Toxicol. Environ. Health B. Crit. Rev. 12(7):509-524.
Crossref
 
Pham AT, Dvergsnes C, Togola A, Wangensteen H, Diallo D, Paulsen BS, Malterud KE (2011). Terminalia macroptera, its current medicinal use and future perspectives. J. Ethnopharmacol. 137:1486–1491.
Crossref
 
Pohl HR, Roney N, Abadin HG (2011). Metal ions affecting the neurological system. Met Ions Life Sci. 8:247-262.
 
Satarug S, Garrett SH, Sens MA, Sens DA (2010). Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 2010 Feb. 118(2):182-190.
Crossref
 
Singh R, Gautam N, Mishra A, Gupta R (2011). Heavy metals and living systems: An overview. Indian J. Pharmacol. 2011 May. 43(3):246-53.
Crossref
 
Silva O, Viegas S, de Mello-Sampayo C, Costa MJ, Serrano R, Cabrita J, Gomes ET (2012). Anti-Helicobacter pylori activity of Terminalia macroptera root. Fitoterapia. 83:872–876.
Crossref
 
Silva O, Gomes ET, Wolfender JL, Marston A, Hostettmann K (2000). Application of high-performance liquid chromatography coupled with ultraviolet spectroscopy and electrospray mass spectrometry to the characterisation of ellagitannins from Terminalia macroptera roots. Pharmaceut. Res. 17:1396–1401.
Crossref
 
Wu Z, Du Y, Xue H, Wu Y, Zhou B (2012). Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Neurobiol Aging. 2012 Jan; 33(1):199.e1-12.
Crossref