African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2294

Full Length Research Paper

Assessment of the usefulness of a traditional therapy N01-KABRAN compared to conventional anti-diabetics in real-life use in a retrospective study

Mamadou KAMAGATE
  • Mamadou KAMAGATE
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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Kanga Sita N’ZOUE
  • Kanga Sita N’ZOUE
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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Thérèse DAUBREY-POTEY
  • Thérèse DAUBREY-POTEY
  • Department of Fundamental and Bioclinical Sciences, Félix Houphouët-Boigny University, Abidjan, Ivory Coast.
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Jean-Claude YAVO
  • Jean-Claude YAVO
  • Department of Fundamental and Bioclinical Sciences, Félix Houphouët-Boigny University, Abidjan, Ivory Coast.
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Augustine KAKOU
  • Augustine KAKOU
  • Department of Fundamental and Bioclinical Sciences, Félix Houphouët-Boigny University, Abidjan, Ivory Coast.
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N’Guessan Alain Roland YAO
  • N’Guessan Alain Roland YAO
  • Department of Fundamental and Bioclinical Sciences, Félix Houphouët-Boigny University, Abidjan, Ivory Coast.
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Camille KOFFI
  • Camille KOFFI
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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N’Goran Mathieu KOUAME
  • N’Goran Mathieu KOUAME
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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Manan Siméon YOBO-BI
  • Manan Siméon YOBO-BI
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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Mankoh Yves-Cédric KEE
  • Mankoh Yves-Cédric KEE
  • Department of Basic and Bioclinical Sciences, Alassane Ouattara University, Bouaké, Ivory Coast.
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Henri DIE-KAKOU
  • Henri DIE-KAKOU
  • Department of Fundamental and Bioclinical Sciences, Félix Houphouët-Boigny University, Abidjan, Ivory Coast.
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  •  Received: 14 May 2024
  •  Accepted: 04 July 2024
  •  Published: 31 October 2024

Abstract

Comparing the quality of life of herbal medicine users with those undergoing anti-diabetic treatments in real-life scenarios for type II diabetes, this retrospective parallel group study focused on follow-up data from medical records of the nine months preceding the survey day of consenting type 2 diabetic patients. The SF-36 questionnaire, translated into French, was used. Alpha was set at 5%. The groups, Classic Antidiabetics (GA, n=60) and Traditional Medicine (GT, n=15), had comparable average ages (52.8 vs. 50 years), body mass index, and sedentary lifestyle. The mean blood glucose at M0 was not different between the groups (1.85 vs. 1.15 g/l, p=0.3). However, the glycemic balance was (7.58 vs. 6.5%, p=0.001). From M0 to M8 follow-up, complications were dominated by hypertensive attacks in GT (85.7%) and hypoglycemia (18.2%) and infections (12.1%) in GA. GT showed poor compliance. Mental health (69.01% vs. 91.61%, p=0.001) and physical health (71.07 vs. 83.65%, p=0.02) were significantly better in GT. On the other hand, physical function (84.04 vs. 94.67%, p=0.06) and physical limitation (60.42 vs. 76.67%, p=0.12) were comparable in the two groups. This study highlighted the usefulness of traditional therapy, as patients on traditional therapy had a better quality of life score with comparable cardiovascular and metabolic risks to those of the antidiabetic group, despite their poor compliance. Further studies are needed to confirm these findings.

Key words: Clinical trials, quality of life, safety, antidiabetics, traditional medicine.