African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2112

Full Length Research Paper

In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice

Olorunniyi, O. F*
  • Olorunniyi, O. F*
  • Department of Zoology, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria.
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O. A. Morenikeji
  • O. A. Morenikeji
  • Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria
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  •  Received: 21 November 2013
  •  Accepted: 14 February 2014
  •  Published: 29 March 2014

Abstract

Antimalarial activity of the crude aqueous leaf extract of Pyrenacantha staudtii was evaluated using chloroquine-sensitive Plasmodium berghei infection in mice with an objective to finding scientific evidence for the use of the plant as traditional antimalarial remedy in Ido/Osi LGA of Ekiti state, Nigeria. The crude aqueous extract of P. staudtii Engl. (Icacinaceae) (100, 200 and 500 mg/kg) was administered orally to mice infected with P. berghei in 4 days suppressive test. The antiplasmodial effect during the test of the plant in blood was determined and the extract at these doses induced 58.0 to 63.4% activity in comparison with untreated (negative) control group. Chloroquine produced 100% activity. The antimalarial activity showed by P. staudtii during the test justifies its use in traditional medicine for treating of malaria in the area.

 

Key words: Pyrenacantha staudtii, herb, malarial, anti-malarial, Ido/Osi, Ekiti, Plasmodium berghei, mice.