African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

Effect of essential oil of Chromoleana odorata (Asteraceae) from Ivory Coast, on cyclooxygenase function of prostagladin-H synthase activity

G. Bedi1*, Z. F. Tonzibo1, K. R. Oussou1, C. Choppard2, J. P. Mahy3 and T. Y. N’Guessan1
1Laboratoire de Chimie Organique Biologique, Université de Cocody, 22 BP 582 Abidjan 22, Côte d’Ivoire. 2Laboratoire de Chimie et  Biochimie Pharmacologique et Toxicologique, UMR 8601 CNRS, Université René – Descartes, Paris Cedex 75270, France. 3Laboratoire de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire et des Matériaux, UMR 8182 CNRS, Bât. 420, Université Paris 11, 91405 Orsay Cedex, France.
Email: [email protected]

  • Article Number - 42104AA26544
  • Vol.4(8), pp. 535 - 538, August 2010
  •  Accepted: 22 July 2010
  •  Published: 31 August 2010

Abstract

Aqueous extracts of Chromoleana odorata are commonly used in traditional medicine as anti inflammatory drug against pains or as cataplasm to stop hemorrhage in Ivory Coast. In this work, we want to test the volatiles as essential oil extracted from the fresh leaves of C. odorata, on the cyclooxygenase function of prostaglandin-H synthase (PGHS), a protein implicated in the inflammatory process. Our goal is to make up the in vivo therapeutic activity and understand the mechanism of its biologic activity. This essential oil is extracted from leaves of C. odorata by hydrodistillation to be submitted to in vitro test. The chemical constituents of the essential oil of C. odorata increase the activity of cyclooxygenase function of PGHS with an AC50 value of 87.5 µg/mL. Studies are in progress to indentify all the constituents implicated in the activity.

 

Key words: Chromoleana odorata, essential oil, cyclooxygenase, PGHS.

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