African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2183

Full Length Research Paper

Treatment with extracts of Eugenia jambolana seed and Aegle marmelos leaf prevents hyperglycemia and hyperlipidemia in alloxan induced diabetic rats

T. Gohil1*, N. Pathak1, N. Jivani1, V. Devmurari1 and J. Patel2
1Smt. R. B. Patel Mahila Pharmacy, College Atkot, Gujarat, India. 2S. K. Patel College of Pharmaceutical Science Education Research Center, Kherava, Gujarat, India.
Email: [email protected]

  • Article Number - 462A3C525706
  • Vol.4(5), pp. 270-275 , May 2010
  •  Accepted: 15 March 2010
  •  Published: 31 May 2010

Abstract

Eugenia jambolana and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of E. jambolana and A. marmelos (EA) on alloxan induced diabetic rats. The diabetes induced animals were fed with plant extracts at the increasing dosage of 200, 300 and 400 mg of body wt. The combined plant extracts administrated animals revealed a significant (P < 0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P < 0.001). The histological studies of the endocrine region of pancreas of diabetic animals revealed that shrinkage of β cells of islets of langerhans. The combined plant extracts treated animals revealed restoration of β-cells. The restoration of β cells was evident at higher dose level that is, 400 mg/by wt extracts fed groups.

 

Key words: Eugenia jambolanaAegle marmelos, alloxan, hyperglycemia, hyperlipidemia.