African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Protective effect of Panax ginseng against N-acetyl-p-amino­phenol-induced hepatotoxicity in rats

Mustafa Uzkeser1, Emre Karakus2, Abdulmecit Albayrak3, İlhami Kiki4, Yasin Bayir5, Elif Cadirci6, Deniz Unal7, Zekai Halici3* and Ali Karadeniz8
1Department of Emergency Medicine, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey. 2Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey. 3Department of Pharmacology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey. 4Department of Internal Medicine, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey. 5Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey. 6Department of Pharmacology, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey. 7Department Histology and Embryology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey. 8Department Physiology, Faculty of Veterinary Medicine, Ataturk University, 25240, Erzurum, Turkey.
Email: [email protected]

  •  Accepted: 03 September 2012
  •  Published: 29 September 2012

Abstract

Panax ginseng (PG) has been commonly used as medicinal herb for the treatment of various diseases in Eastern Asia for thousands of years. This study was designed to investigate the protective effect of PG against paracetamol-(N-acetyl-p-amino­phenol; APAP)-induced liver damage in rats. Thirty-two albino Wistar rats were divided into four groups: Group C (control); Group APAP (gavaged orally with APAP (APAP, 2 g/kg, single dose); Group PG 100 mg/kg + APAP or 200 mg/kg + APAP (these two groups were treated by gavaging with PG (100 or 200 mg/kg) for 30 days following a single dose of APAP). APAP treatment alone induced hepatotoxicity, evidenced by significant increases in malondialdehyde (MDA) level and serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and tumor necrosis factor-α (TNF-α). In addition, the level of GSH in the liver was significantly reduced, as were the activities of superoxide dismutase (SOD) and catalase (CAT). Liver histopathological examination showed that APAP administration induced centrilobular necrosis and infiltration of lymphocytes. However, these biochemical and histological changes were prevented by PG pretreatment. In conclusion, our results suggest that PG may be considered a protective medicinal herb against APAP-induced liver injury.

 

Key words: Panax ginseng, N-acetyl-p-amino­phenol, liver, oxidative damage, rat.

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