African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

Activity induced by Jatropha gaumeri on glucose concentration in a rat diabetic model

Elodia García-Cervera1, Lauro Figueroa-Valverde1*, Francisco Díaz-Cedillo2, Eduardo Pool-Gómez1, Rogaciano Torrez-Cutz1 and Rubí Martinez-Camacho3
1Lab. Farmacoquímica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C.P.24039 Campeche Cam., México. 2Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340. 3Instituto Tecnológico de la Paz. Blvd. Forjadores de Baja California Sur No. 4720, Col. 8 de octubre, 1era Secc., C.P. 23080 La Paz Baja California, México.  
Email: [email protected]

  •  Accepted: 15 August 2012
  •  Published: 15 September 2012

Abstract

Since several years ago, some medicinal plants are being used for the treatment of diabetes. In this study the activity of Jatropha gaumeri on glucose concentration was evaluated in a diabetic rat model. This involves the induction of diabetes in the animal of study with alloxan, then the ethanolic extract of J. gaumeri leaves was administered orally at different doses to diabetic rats. The determination of glucose concentration was quantified every 24 h for one month before and after the gastric administration of each extract. The hypoglycemic effect ofJ. gaumeri was compared with the activity induced by glibenclamide and metformine. The results indicate that hypoglycemic effect exerted by the ethanolic extract of J. gaumeri was in a dose-dependent manner and different with both metformin and glibenclamide. These results suggest that hypoglycemic activity induced by J. gaumeri is a dose dependent manner.

 

Key words: Jatropha gaumeri, metformine, glibenclamide.

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