Since several years ago, some medicinal plants are being used for the treatment of diabetes. In this study the activity of Jatropha gaumeri on glucose concentration was evaluated in a diabetic rat model. This involves the induction of diabetes in the animal of study with alloxan, then the ethanolic extract of J. gaumeri leaves was administered orally at different doses to diabetic rats. The determination of glucose concentration was quantified every 24 h for one month before and after the gastric administration of each extract. The hypoglycemic effect ofJ. gaumeri was compared with the activity induced by glibenclamide and metformine. The results indicate that hypoglycemic effect exerted by the ethanolic extract of J. gaumeri was in a dose-dependent manner and different with both metformin and glibenclamide. These results suggest that hypoglycemic activity induced by J. gaumeri is a dose dependent manner.
Key words: Jatropha gaumeri, metformine, glibenclamide.
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