African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Patterns of drugs prescribed concomitantly with levothyroxine in children with hypothyroidism

Adrián Guillé Pérez1, Guadalupe Camacho Vieyra1, Alejandra Toledo López1, Hugo Juárez Olguín1,2 and Gabriela Pérez Guillé1*    
1Laboratorio de Farmacología, Instituto Nacional de Pediatría, CP 04530, Mexico City, Mexico. 2Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, CP 04130, Mexico City, Mexico.    
Email: [email protected]

  •  Accepted: 23 April 2012
  •  Published: 08 May 2012

Abstract

The aim of this work was to know the prescription pattern of drugs for the treatment of concomitant pathologies in children with hypothyroidism, who were receiving levothyroxine, so as to identify drugs with possible interaction risk and avoid the production of adverse effects. An analysis of treatments in children diagnosed of hypothyroidism treated with levothyroxine and medicines added for the treatment of concomitant pathologies in an endocrinology service from December 1999 to December 2009 was carried out. For capturing the information, a form for information gathering was used and the Naranjo causality algorithm was used. 475 clinical files corresponding to 292 (61.47%) females and 183 (38.53%) males were reviewed. The concomitant pathologies most frequently seen were gastrointestinal (60.47%) and respiratory diseases with 55.58%. The number of drugs simultaneously administered with levothyroxine was from 1 to 7. Applying the Naranjo algorithm, 38.5% were adverse drug reactions (ADRs) definite, 23% ADRs probable, 23% ADRs possible and 4% doubtful. In conclusion, the prescription of drugs co-administered simultaneously with levothyroxine should be done in a rational form because there are drugs as anticonvulsant, diuretics or gastrointestinal that can interact between them as with levothyroxine, principally with drugs administered in a chronic form.

 

Key words: Children, hypothyroidism, levothyroxine, pharmacoepidemiology.

  • Articles on Google by: