African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2268


Antiplasmodial activity of various parts of Phyllanthus niruri according to its geographical distribution

P. Njomnang Soh1,2, J. T. Banzouzi3,4, H. Mangombo5, M. Lusakibanza5, F. O. Bulubulu6, L. Tona5, A. N. Diamuini6, S. N. Luyindula6 and Françoise Benoit-Vical1,2*
1Parasitology-Mycology Department, Rangueil Hospital University, TSA 50032, 31059 Toulouse 9, France & University of Toulouse, 31059 Toulouse Cedex 9, France. 2CNRS ; LCC UPR8241; 205, route de Narbonne, F-31077 Toulouse, France AND University of Toulouse ; UPS, LCC ; F-31077 Toulouse, France. 3ICSN-CNRS UPR2301, 91198 Gif-sur-Yvette cedex, France. 4CERMA, Médecins d’Afrique, BP 45, Brazzaville, Congo. 5Pharmacology Laboratory, University of Kinshasa, RD Congo. 6International Atomic Energy Agency (IAEA) , BP 868. Kinshasa XI, RD Congo.
Email: [email protected]

  •  Accepted: 15 October 2006
  •  Published: 31 December 2009


Extracts of Phyllanthus niruri L., collected from three different areas in the Congo (Kisantu, Kimwenza and University of Kinshasa), used for malaria treatment were tested in vitro in order to evaluate their antiplasmodial properties. Whereas the whole plant is traditionally used, aqueous extracts of the various parts of the P. niruri plant (stems, leaves and roots) tested on the chloroquine-resistant strain FcM29-Cameroon showed that only the leaves and the stems presented real in vitro antiplasmodial activity without any cytotoxicity. This information is particularly important because the leaves are affordable and their use is less damaging to plant stocks.


Key words: Ethno-pharmacology, Plasmodium falciparum, harvest areas, parts of plant.