The main aim of the present investigation was to develop sustained release (SR) floating drug delivery system (FDDS) of sodium salicylate using k-carrageenan as the sustained release matrix. Varying w/w concentration ratios of drug and polymer dispersion ranging from 1:0 to 1:1 were selected from the preliminary trials for this investigation made from batches granulated with isopropyl alcohol containing, in addition, the same w/w concentration of: PVP K30; magnesium stearate and talc. Equal concentrations of citric acid and optimum concentration of sodium bicarbonate in the various batches were used to induce the generation of CO2. The physical properties of the various matrices were studied. The in vitro buoyancy lag time (BLT), total floating time (TFT) and in vitro drug release of the tablets were studied in 0.1 N HCl. The results show that BLT ranged from 50 to 55 s, while the TFT were significantly higher than 12 h (p < 0.05) for most batches. Results of in vitro release show that about 97, 80, 86.1, 53.4, 64.4 and 47.7% of drug were released at 6 h, respectively from batches F1, F4, F5, F6, F7 and F8. Therefore, carrageenan presented good matrix for the formulation of sustained release sodium salicylate floating tablets and could be used at ratios 1: 0.87, 1: 0.67 and 1: 0.53 (drug: polymer) combination for SR sodium salicylate tablets.
Key words: Carrageenan, bio-adhesion, sustained release, floating drug delivery, nonsteroidal antiinflammatory drugs (NSAIDs).
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