Full Length Research Paper
Abstract
Gentamicin (GM) is an aminoglycoside antibiotic which is used in clinical practice to treat severe gram-negative infections. Silybum marianum, also known as milk thistle, is a member of Asteraceae family and is well recognized as a hepatoprotective herbal medicine. The main objective of this present study was to evaluate the renoprotective effect of silymarin on GM-induced nephropathy. Eighteen healthy Ghezel sheep were randomly divided into three groups of control and treatments. All sheep of two groups received 20 mg/kg/body weight of GM every 8 h by intramuscular injection for 10 days. Treatment group also receive silymarin at the dose of 80 mg/case three-times a day for 20 days intramuscular injection for 14 days. This study showed that the GM-induced renal toxicity, as measured by multiple functional, structural and enzymatic factors is significantly reduced by co-supplementation of silymarin. The results of this study suggest the potential of silymarin to protect against GM-induced nephrotoxicity.
Key words: Renoprotection, silymarin, gentamicin, nephropathy.
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