African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2106

Full Length Research Paper

Electrocatalytic determination of anti-hyperthyroid drug, methimazole, using a modified carbon-paste electrode

Fahimeh Jalali1*, Loghman Miri1 and Mahmoud Roushani2
1Department of Chemistry, Razi University, Kermanshah, 67346, Iran. 2Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran.
Email: [email protected]

  •  Accepted: 14 September 2012
  •  Published: 15 February 2013

Abstract

The preparation and electrochemical behavior of a carbon-paste electrode modified with an oxovanadium (IV) Schiff-base complex was studied. The modified electrode showed efficient catalysis in the electrochemical oxidation of methimazole (MMZ), an anti-hyperthyroid drug. The catalytic effect was observed for VIII oxidation peak which was produced via disproportionation of VIV in acidic solution. The diffusion coefficient (D) of MMZ and the rate constant of catalytic reaction (k) were estimated by chronoamperometry. Determination of MMZ was carried out using differential pulse voltametry. A linear dynamic range of 9 × 10–7 to 1 × 10-4 M with a detection limit of 8 × 10-7 M and a limit of quantitation of 2.6 × 10–6 M was resulted for the drug. The relative standard deviation for determination of 20 μM of the drug was found to be 1.7%. The method was used for the quantitation of MMZ in pharmaceutical formulations successfully.

 

Key words: Methimazole, determination, tablets, modified-carbon paste electrode.