African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2194

Full Length Research Paper

In vitro antioxidant activity of diazenyl schiff base molecules

Mohanta G. P.
  • Mohanta G. P.
  • Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India.
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Sarangi P. K. N.
  • Sarangi P. K. N.
  • Department of Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, India.
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Paidesetty S. K.
  • Paidesetty S. K.
  • Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, India.
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  •  Received: 21 March 2017
  •  Accepted: 07 April 2017
  •  Published: 22 May 2017

Abstract

A series of several diazenyl schiff base molecules were designed and synthesized through azo coupling of  diazotised primary amines with the novel synthesized schiff base ligand (E)-N-((2-chloroquinolin-3-yl)methylene)-4-phenylthiazol-2-amine. All the synthesized molecules have been characterized by different spectral techniques for their structural confirmation. The results of in vitro antioxidant activity of the molecules by 2,2-diphenyl-1- picryl hydrazyl (DPPH) assay method revealed that the molecules (NZ)-N-(((4-chlorophenyl) diazenyl) (2-chloroquinolin-3-yl) methylene) -4- phenylthiazol -2-amine (5A) and 4-(((Z)-(2-chloroquinolin-3-yl)(4-phenylthiazol-2-ylimino)methyl)diazenyl)phenol (5E) have shown potential free radical scavenging activity.

Key words: Schiff base, diazenyl, spectral, antioxidant.