African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2191

Full Length Research Paper

Evaluation of the effect of omega-3 supplements in the prevention of preeclampsia among high risk women

Fatemeh Lalooha1, Talaat Dabbaghi Ghaleh1, Hamideh Pakniiat1, Fatemeh Ranjkesh2, Toba gholshahi2 and Omid Mashrabi3*
1Faculty of Medicine, Ghazvin University of Medical Sciences, Ghazvin, Iran. 2Faculty of Nursing and Midwifery, Ghazvin University of Medical Sciences, Ghazvin, Iran. 3Women's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]

  •  Accepted: 10 August 2012
  •  Published: 22 September 2012


Identification of proactive preeclamptic factors in pregnant women, as one of the three maternal and neonatal mortality factors, is of special importance. Omega-3 is a polyunsaturated fatty acid that may reduce blood pressure and brain and heart attacks affecting the production of prostaglandins and reducing unwanted fat, vasodilatation and platelet adhesion. This study was designed and implemented to clinically evaluate the effect of omega-3 supplements in preventing preeclampsia among high risk women of Qazvin city. In a double-blinded clinical trial, 100 high risk preeclamptic women were selected by target-based sampling from among pregnant women referred to health centers in Qazvin city, and voluntarily enrolled into the study. Then, samples were randomly divided into two treatment groups with omega-3 supplementation and placebo, respectively. The population was monitored until termination of pregnancy and childbirth, and post-delivery information was collected and statistically analyzed. Incidence and severity of preeclampsia among the mothers receiving omega-3 supplement 1 g daily during pregnancy was significantly less than that in the control group (p = 0.015). The outcome of pregnancy, including birth time zone and minute 5 Apgar score of neonates in omega-3 group were significantly greater than in the control group. Mean systolic and diastolic blood pressure in omega-3 group was significantly less than that in the control group. Using Omega-3 supplement is effective in reducing incidence of preeclampsia and its severity. It is also effective on improving pregnancy outcome, including birth weight and neonatal minute 5 Apgar score. Therefore, development of nutritional education programs for pregnant women seems to be necessary.


Key words: High-risk pregnancy, preeclampsia, omega-3.