African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2198

Full Length Research Paper

A novel pentacyclic triterpene glycoside from a resin of Commiphora glandulosa from Botswana

Daniel Motlhanka1*, Peter Houghton2, Ana Miljkovic-Brake2 and Solomon Habtemariam3
1Medicinal Plant Research Laboratories, Basic Sciences Department Botswana College of Agriculture, Bag 0027 Gaborone, Botswana. 2Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King’s College, University of London, 150 Stamford Street, SE1 9NH, London, UK. 3Pharmacognosy and Phytotherapy Research Laboratories, School of Chemical and Life Sciences, University of Greenwich at Meadway, Central Avenue, Chatham Maritime, Kent, ME4 4TB, Kent, UK.
Email: [email protected]

  •  Accepted: 13 August 2010
  •  Published: 31 August 2010

Abstract

A novel ursane-type pentacyclic triterpene glycoside, 1b,2b,3b-trihydoxy-urs-12-ene-23-oic-rhamnoside was isolated from the resin of Commiphora glandulosaSchinz by bioassay guided fractionation. Crude aqueous and chloroform extracts of the resin as well as the isolated compound exhibited good in vitro antibacterial activity against gram positive bacteria (Bacillus subtilis: NCTC 10073), (Clostridium perfringens: NCTC 8237), (Staphylococcus aureus: NCIMB 9518) and also drug resistant strains (S.aureus:XU212-tetracycline resistant strain), (S. aureus SA1199B-norfloxacin resistant strain). There was no observed antimicrobial activity against gram negative bacteria (Escherichia coli: NCTC 9002), (Pseudomonas aeruginosa: NCIMB 10421), (Klebsiella aerogenes: NCTC 5055); and fungal strains (Candida albicans: NCPF 3179, Aspergillus fumigatus: NCPF 7097), Trichophyton tonsurans: NCPF 995). The structure of the isolated compound was elucidated on the basis of spectral data using13C-NMR, 1H-NMR and mass spectroscopy.

 

Key words: Commiphora glandulosa resins, antibacterial activity, novel pentacyclic triterpene, Botswana medicinal plants, antibacterial activity.