African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2298

Full Length Research Paper

Characterization and antioxidant activity of the complex of sesamol and hydroxypropyl-β-cyclodextrin

Yuxiang Ma1*, Li Yang2, Chungang Chen3, Yang Liu3 and Xuede Wang1
1College of Grain and Food, Henan University of Technology, Zhengzhou 450052, China. 2Lab Center, Henan Institute of Science and Technology, Xinxiang 453003, China. 3School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China.
Email: [email protected]

  •  Accepted: 11 April 2012
  •  Published: 29 April 2012

Abstract

Sesamol is a natural antioxidant with good prospect in food and medicine industry. But its poor water solubility limits its application. In this study, the complex of sesamol and HP-β-CD was prepared to improve the water solubility of sesamol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The result showed that sesamol in the complex had been molecularly dispersed in the HP-β-CD matrix, not forming a new compound. And the complex was an effective scavenger of DPPH radicals. A linear correlation between concentration of the complex and reducing power was also observed.

 

Key words: Sesamol, hydroxypropyl-β-cyclodextrin, complex, antioxidant.