African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2195

Full Length Research Paper

Controlled release formulation of levocetirizine dihydrochloride by casein microparticles

Vino, S.*, Preethi lakshmi R., Gopika, M. and Ghosh, A. R.
Medical Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore 632 014, Tamilnadu, India.
Email: [email protected]

  •  Accepted: 05 March 2013
  •  Published: 08 May 2013

Abstract

The study aims to develop a microparticulate casein based delivery system by the controlled drug delivery approach using Levocetirizine dihydrochloride as the model drug. Fourier transform infrared spectroscopy (FTIR), X-ray and differential scanning calorimetry (DSC) studies substantially indicates the presence of molecularly dispersed drug within the particles with preserved stability during microencapsulation. In vitro release studies of levocetirizine dihydrochloride loaded microparticles were performed by simulating the condition of gastrointestinal tract, and showed the minimal drug leakage (less than 5%) at acidic pH (1.2) and significantly higher release at basic pH (7.4). The results were found to be critical in confirming the role of casein microparticles as potential candidate for the controlled and targeted release of levocetirizine dihydrochloride.

 

Key words: Extended release, casein, levocetirizine dihydrochloride, steric stabilization.