African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2188

Full Length Research Paper

Anti-inflammatory and analgesic activities of extracts from Balanites aegyptiaca L. Delile (Balanitaceae) root bark: Plant used against liver diseases in Bukina Faso

Kadiatou Tata Traoré
  • Kadiatou Tata Traoré
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Noufou Ouédraogo
  • Noufou Ouédraogo
  • Laboratoire du Développement des Médicaments (LADME), Ecole Doctorale de la Santé, Université Joseph Ki-Zerbo, 03 BP 7021, Ouagadougou 03, Burkina Faso.
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Lazare Belemnaba
  • Lazare Belemnaba
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Gilchrist Abdoul Laurent Boly
  • Gilchrist Abdoul Laurent Boly
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Leïla Marie Esther W. Kabré
  • Leïla Marie Esther W. Kabré
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Constantin B. Atchadé
  • Constantin B. Atchadé
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Mohamed B. Belemlilga
  • Mohamed B. Belemlilga
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Sylvain Ilboudo
  • Sylvain Ilboudo
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Marius Lompo
  • Marius Lompo
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Sylvin Ouédraogo
  • Sylvin Ouédraogo
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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André Tibiri
  • André Tibiri
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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Innocent Pierre Guissou
  • Innocent Pierre Guissou
  • Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
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  •  Received: 10 October 2019
  •  Accepted: 18 November 2019
  •  Published: 31 December 2019

Abstract

Balanites aegyptiaca (L.) Del has been used in various traditional medicines against inflammation and pain. The aim of this study was to evaluate the enzymatic, anti-oedmeatous and analgesic activities of ethanolic and aqueous extracts of Balanites aegyptiaca (L.) Del root bark in mice. The extracts were tested in vitro for their ability to inhibit the enzymes cyclooxygenase (COX)-1 and COX-2, 15-lipoxygenase (LOX) and phospholipase (sPLA2). The anti-inflammatory and analgesic activity of ethanolic and aqueous extracts was determined by oral administration to healthy animals at doses of 100, 200, 400 and 600 mg/kg and their involvement in KATP pathways was verified. The percentage inhibition of the activity of the enzyme phospholipase A2 was close to 50%, those of COXs (COX 1 and COX 2) comparable to those of the control. It has an ability to inhibit 15-LOX even if the IC 50 is lower than that of the reference compound (Zileuton). Pretreatment with the extract at doses of 100 to 600 mg/kg significantly reduced carrageenan-induced edema from 54.91 to 71.80%. The action of the extract significantly decreased the number of contortions with a percentage inhibition greater than 50% for doses of 400 and 600 mg/kg. The action of the extract is not involved in potassium channels (KATP) in nociception. Pharmacological observed activities provide the scientific basis for the medicinal use of the plant in the treatment of acute inflammation.

Key words: Balanites argyptiaca, phospholipase A2, cyclooxygenases, lipoxygenase, anti-edema activity, analgesic.