African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

Effect of dexamethasone on the NT-4/5 expression of hippocampus and neocortex in young rats with Streptococcus pneumoniae meningitis

Hong Zhang1, Hongyu Qian2 and Ling Li3*
1Department of Emergency Pediatrics, The People's Hospital of Liaocheng City, Liaocheng 252000, China. 2Department of Pediatrics, Brain Hospital, The People's Hospital of Liaocheng City, Liaocheng 252000, China. 3Department of Pediatrics, Xinhua Hospital, The Affiliated Hospital to Shanghai Jiaotong University, Shanghai 200092, China.
Email: [email protected]

  •  Accepted: 23 August 2012
  •  Published: 15 September 2012

Abstract

The aim of this study was to investigate the effect of dexamethasone (DEX) adjuvant therapyon the neurotrophin-4/5(NT-4/5) expression of hippocampus and neocortex in young rats withStreptococcus pneumoniae meningitis. Three-week-old rat models with S. pneumoniaemeningitis were established; there were 32 rats, receiving antibiotics and antibiotics with DEX treatments, respectively. The NT-4/5 expression of hippocampus and neocortex were detected through immunohistochemical techniques. The NT-4/5 expression in the antibiotics with DEX treatment group was significantly higher than that of the simple antibiotics treatment (P<0.05). The immunohistochemical staining-positive particles were undetected in the negative control. S. pneumonia meningitis treated with DEX adjuvant therapy can regulate NT-4/5 expression to promote nerve growth, thus, reducing the damage to brain parenchyma.

 

Key words: Meningitis, Streptococcus pneumonia, neurotrophin-4/5, antibiotics, dexamethasone.

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