The aim of this study was to investigate the effect of dexamethasone (DEX) adjuvant therapyon the neurotrophin-4/5(NT-4/5) expression of hippocampus and neocortex in young rats withStreptococcus pneumoniae meningitis. Three-week-old rat models with S. pneumoniaemeningitis were established; there were 32 rats, receiving antibiotics and antibiotics with DEX treatments, respectively. The NT-4/5 expression of hippocampus and neocortex were detected through immunohistochemical techniques. The NT-4/5 expression in the antibiotics with DEX treatment group was significantly higher than that of the simple antibiotics treatment (P<0.05). The immunohistochemical staining-positive particles were undetected in the negative control. S. pneumonia meningitis treated with DEX adjuvant therapy can regulate NT-4/5 expression to promote nerve growth, thus, reducing the damage to brain parenchyma.
Key words: Meningitis, Streptococcus pneumonia, neurotrophin-4/5, antibiotics, dexamethasone.
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