African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2162

Full Length Research Paper

A randomized double-blind controlled study of the efficacy of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy

Yanfen Wang1, Xi Jiang2, Lei Pang3, Su Dong3, Yanhua Feng3, Sujan Surya Prajapati3,Changji Yuan2 and Haichun Ma3*
1Department of Gastroenterology, the Second Hospital of Jilin University, Jilin, Changchun, China. 2The Cancer Center, the First Hospital of Jilin University, Jilin, Changchun, China. 3Department of anesthesiology, the First Hospital of Jilin University, Jilin, Changchun, China.
Email: [email protected]

  •  Accepted: 15 August 2012
  •  Published: 15 September 2012

Abstract

The objectives of this study are to compare the effectiveness of different proportions of ketamine and propofol in ketamine-propofol single-syringe combination (ketofol), and to compare the effectiveness of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy. Randomized, double-blind, controlled study of 100 female American Society of Anesthesiologists (ASA I or II) patients of age 18 to 40 years undergoing abortion was used. Patients were randomly divided into 5 groups of 20. Groups K21, K31, and K41 were given ketofol intravenously in the ratios of propofol:ketamine, 2:1, 3:1, and 4:1, respectively in small aliquots; group PF was given 1.5 to 2 mg/kg propofol and 50 mcg fentanyl, whereas group P was given only 2 mg/kg propofol. Blood pressure, heart rate, oxygen saturation; surgery, anesthesia, sedation, recovery, and discharge times were recorded. There was significant difference (P<0.05) in anesthesia, sedation, and discharge times. Group K21 had higher sedation, recovery, and discharge times than the other groups. All ketofol groups had high incidence of postoperative dizziness, whereas the non-ketofol groups had high incidence of intraoperative respiratory depression. Ketofol groups required less dosage of propofol than the non-ketofol groups with group P requiring the highest (3.5±0.6 mg/kg). Ketofol is as effective as propofol-fentanyl combination, especially in the ratios 3:1 and 4:1 (propofol:ketamine) for abortion.

 

Key words: Ketofol, ketamine, propofol, fentanyl, procedural sedation, abortion.

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