African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2188

Full Length Research Paper

Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots

E. Boakye-Gyasi , E. Woode, G. K. Ainooson, D. D. Obiri , C. Ansah ,  Duwejua M. and  Donkoh A.
1Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. 2Department of Clinical and Social Pharmacy, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. 3Department of Animal Science, College of Agriculture and Renewable Resources, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Email: [email protected] or [email protected]

  •  Accepted: 11 November 2008
  •  Published: 30 November 2008

Abstract

The effect of Palisota hirsuta root ethanolic extract, a herbal preparation used in Ghana for pain and inflammatory disorders, was assessed in acute inflammation in carrageenan-induced foot oedema in chicks and brewer’s yeast-induced pyrexia in rats. Two paradigms were used for the inflammation assessment; effect of the extract on established inflammation (curative protocol) and effect before the induction of inflammation (preemptive protocol). P. hirsuta extract (50 - 400 mg/kg, p.o) dose-dependently reduced foot oedema with maximal effect of 58.90 ± 11.38% (prophylactic) and 62.52 ± 4.73% (curative). Similarly, the NSAID, diclofenac (10 - 100 mg/kg, i.p.) used as a reference drug, dose-dependently reduced the oedema with a maximal effect of 96.82 ± 3.64% (prophylactic) and 60.74 ± 5.58% (curative). The steroidal anti-inflammatory drug, dexamethasone (0.5 - 2 mg/kg, i.p), inhibited the oedema with a maximal effect of 86.51 ± 2.61% (prophylactic) and 55.76 ± 9.56% (curative). In terms of potency, the ethanolic extract of P. hirsuta exhibited similar potency when it was administered 1 h before (ED50 178.00 ± 56.8 mg/ kg) and 1 h after (ED50 181.10 ± 49.89 mg/kg) carrageenan injection and this was found to be less potent than both dexamethasone and diclofenac in both the prophylactic and curative protocols. Also, PHE caused a significant dose-dependent decrease in yeast-induced pyrexia in rats (IC50: 265.10 ± 63.73 mg/kg) which was » 15 times less potent than the standard, paracetamol (IC50: 18.05 ± 4.08 mg/kg). The results thus confirm the use of the plant for inflammatory disorders in traditional medicine.

 Key words: Palisota hirsuta, carrageenan, yeast, chicks, rats.