African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2227

Full Length Research Paper

Effect of aqueous extract of Chrysophyllum cainito leaves on the glycaemia of diabetic rabbits

N'guessan Koffi1*, Amoikon Kouakou Ernest3, Tiébré Marie-Solange1, Kadja Beugré2 and Zirihi Guédé Noël1
1University of Cocody-Abidjan (Côte-d’Ivoire), Unity of Formation and Research (U. F. R.) Biosciences; Laboratory of Botany; 22 BP 582 Abidjan 22 (Côte-d’Ivoire). 2University of Cocody-Abidjan, U. F. R. Biosciences, Laboratory of Biochemistry, Abidjan, Côte-d’Ivoire 3University of Cocody-Abidjan, U. F. R. Biosciences, Laboratory of AnimalPhysiology, Abidjan, Côte-d’Ivoire.
Email: [email protected]

  •  Accepted: 04 September 2009
  •  Published: 28 February 2011

Abstract

Chrysophyllum cainito is a plant recognized by the traditional healers of Aboudé-Mandéké, a village in the Department of Agboville (Côte-d’Ivoire), as having antidiabetic properties. The aim of this study is to evaluate, experimentally, the effect of an aqueous decoction of the plant’s leaves that we called C. cainito, on rabbits induced with alloxane, a diabetogenic product. Different graded doses of this herbal medicine were applied on postprandial blood sugar levels of diabetic rabbits.At doses of 10 g/l, C. cainito does not induce the hypoglycaemic effect. A dose of20 g/l reduced the hyperglycaemia from 5 g/l to 1.4 g/l.  A dose of 30 g/l of C. cainito produced a graded decrease in hyperglycaemia from 6.3 g/l to 3.2 g/l. After 6 weeks of treatment, the induced diabetic rabbits stopped eating and succumbedbetween the 8th and the 9th weeks of experimentation.  It was thus concluded thatC. cainito leaves have glucose lowering effect at doses > 10 g/l and appears toxic and lethal at 30 g/l. C. cainito produces its hypoglycaemic effect mainly throughalkaloids, sterols or triterpens, the antidiabetic active constituents.

 

Key words: Aboudé-Mandéké, alloxan, Côte-d’Ivoire, herbal medicine, traditional healer.