African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2220

Full Length Research Paper

Importance of white flowered Mirabilis jalapa with respect to its phytochemical and antimicrobial screening

Naveed Ullah1*, Mir Azam Khan1, Haider Ali1, Nouman Altaf1, Shakoor Ahmad2, Ghayour Ahmed1 and Minhaj ud Din3
1Department of Pharmacy, University of Malakand Chakdara, Pakistan.  2Department of Biological Chemistry, Rothamsted Research Harpendon, UK.  3Department of Pharmacy, the Islamia University Bahawalpur, Pakistan.
Email: [email protected], [email protected]

  •  Accepted: 09 November 2011
  •  Published: 29 December 2011

Abstract

The aqueous and ethanolic extract derived from the leaves of white flowered plant of Mirabilis jalapa L. were screened for antibacterial activities against Staphylococcus aureus, Salmonella typhi, Escherichia coli, Vibrio cholerae and Bacillus subtilis. Aqueous extracts did not display any inhibition to the tested bacteria. However, all the ethanolic extracts showed good antibacterial activity against the selected pathogensThe growth inhibitions (%) were calculated with reference to the activities of tetracycline which was taken as a standard (100%). Further, the qualitative phytochemical screening of methanolic extract of white flowered plant reveals the presence of trace amount of tannins, moderate amount of alkaloids, carbohydrates, terpenes and saponins. Glycosides and flavonoids were not observed as a notable amount. pH of the methanolic extract was found neutral. The research indicated clearly that white flowered plant ofM. jalapa has strong antibacterial potential and is active against a wide range of microorganisms.

 

Key words: Mirabilis jalapa, phytochemical screening, antibacterial activity.