African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2165

Full Length Research Paper

Protective response to Sulfadoxine-pyrimethamine during intermittent presumptive treatment of malaria in pregnant women in Sagamu, Nigeria

Ahmed A. Adedeji1*, Ernest Tambo1, Fatai A. Fehintola2, Mufliat Akinwunmi1, Olubukola A. Tikare1, Oriola I. Mebude1 and Olusoji E. Jagun3
1Department of Pharmacology, Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University, Sagamu, Nigeria. 2Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. 3Department of Obstetrics and Gynaecology, Olabisi Onabanjo University, Sagamu, Nigeria.
Email: [email protected]

  • Article Number - EF7071F30130
  • Vol.4(10), pp. 754 - 759, October 2010
  •  Accepted: 19 October 2010
  •  Published: 31 October 2010


We study the protective response to sulfadoxine-pyrimethamine (SP) during intermittent presumptive treatment (IPT) of malaria in pregnant women. Pregnant women attending the antenatal service of the primary health centre in Sagamu, Nigeria were enrolled into the study. In addition to the usual treatment with haematinics, participants were randomized into two treatments; SP treated (SPTG) and no SP treated (NSPTG) groups. Information on methods of protection against malaria infection and previous use of IPT was obtained from the participants. All participants were followed up for eight weeks and monitored for peripheral parasitaemia using microscopy. Of the 242 pregnant women enrolled 165(68.2%) pregnant women used at least one form of anti-vector measure; insecticide spray was most common. 186 (76.9%) of these participant had no knowledge of the IPT. Parasite Suppression and malaria pigment-clusters clearance were similar in the two groups. Although knowledge of IPT among pregnant women in the area remains low, use of high anti-vectors in pregnant women population may complement, but blur, the effect of IPT on malaria parasite.


Key words: Intermittent presumptive treatment, malaria, pregnant women, sulfadoxine-pyrimethamine, insecticide.

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