African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2148

Full Length Research Paper

Tolerance and observance of methotrexate in the treatment of rheumatoid arthritis at the university Hospital Bogodogo, Burkina Faso

R. Frank E. Zongo
  • R. Frank E. Zongo
  • Département Pharmacie Hospitalière, Centre Hospitalier Universitaire Yalgado Ouédraogo, Burkina Faso.
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Joelle S. Zabsonre
  • Joelle S. Zabsonre
  • Unité de Formation et de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki Zerbo, Burkina Faso.
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Aminata Nacoulma
  • Aminata Nacoulma
  • Unité de Formation et de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki Zerbo, Burkina Faso.
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Souleymane Fofana
  • Souleymane Fofana
  • Institut des sciences de la santé, Université NAZI BONI, Burkina Faso.
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Moise W. Sawadogo
  • Moise W. Sawadogo
  • Unité de Formation et de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki Zerbo, Burkina Faso.
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Estelle Noella Youl
  • Estelle Noella Youl
  • Département Pharmacie Hospitalière, Centre Hospitalier Universitaire Yalgado Ouédraogo, Burkina Faso.
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Moussa Ouédraogo
  • Moussa Ouédraogo
  • Unité de Formation et de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki Zerbo, Burkina Faso.
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Dieu-Donné Ouédraogo
  • Dieu-Donné Ouédraogo
  • Unité de Formation et de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki Zerbo, Burkina Faso.
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  •  Received: 31 March 2019
  •  Accepted: 19 July 2019
  •  Published: 30 September 2019

Abstract

This study is aimed at assessing tolerance and observance of the patients with RA (rheumatoid arthritis) treated by methotrexate at University Hospital Bogodogo, in Burkina Faso. A cross-sectional study was conducted from July to September 2015 in outpatients with rheumatoid arthritis monitored in rheumatology service. Data were obtained from interview, by reviewing medical cards of the patients and consultation report forms. In total, 205 patients with RA were included. Among them, 135 were treated with methotrexate (65.9%). All patients treated with methotrexate took folic acid tablet weekly. The duration of RA evolution varied from 1 to 360 months with a mean of 48 month. The mean duration of treatment with methotrexate was 30.2 months. Among the patients treated with methotrexate, 28.8% observed adverse reactions, 53.3% declare taking their medication without break during the last month. Discomfort (8.9%) and nausea (5.9%) were the most frequent adverse effects. Stock out of methotrexate in community pharmacy (10.4%) and adverse effect (5.9%) were the main reasons of patient’s inobservance. Methotrexate is always the cornerstone of RA treatment. This study confirms the good tolerance of methotrexate and difficulty of observance with this treatment.

Key words: Rheumatoid arthritis, observance, methotrexate, tolerance, Burkina Faso.