African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2276

Full Length Research Paper

Evaluation of biochemical findings in mice exposed to thiamphenicol treatment

Adnan Adil Hismiogullari1*, Sahver Ege Hismiogullari2, Ozlem Yavuz1, Dinc Essiz3, and Khalid Rahman4
1Department of Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey. 2Department of Pharmacology and Toxicology, School of Veterinary Medicine, Balikesir University, Balikesir, Turkey. 3Department of Pharmacology and Toxicology, School of Veterinary Medicine, Kafkas University, Kars, Turkey. 4School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.  
Email: [email protected]

  •  Published: 31 March 2011

Abstract

The aim of the study was to investigate the acute and subacute dose and the dose regime of thiamphenicol-induced changes in serum biochemical parameters in mice. Thiamphenicol was given to the trial groups at a dosage of 100 mg/kg bw (group 2) and 200 mg/kg bw (group 3) in drinking water for 7 days. Blood samples were collected from all animals on days 1, 3, 7 and 14 of the study. Serum concentrations of urea, creatinin, triglyceride and total protein as well as serum activities of hepatotoxicity markers as ALT, AST, LDH and ALP were measured spectrophotometrically. The results obtained in this study show that oral administration of thiamphenicol in mice do not show biochemical alterations.

 

Key words: Antibiotic, biochemical parameters, hepatotoxicity, mice, thiamphenicol.

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