African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2232

Article in Press

Characterization of native, acetylated and enzymatically modified amura starch (Taccainvolucrata) for tablets binding

Abubakar M, Dickson M and Evans Egwim

  •  Received: 25 September 2021
  •  Accepted: 08 November 2021
This research is aimed at producing alternative starch used for tablet binding from amura tuber. The Microbiological properties of native and modified amura were determined for bacteria and Fungi load using plate counting method. The physicochemical properties of the native and modified amura starches were determining using standard method, amylose and amylopectin content of native and modified amura starches were determining using spectrophotometric method. The comparative binding and disintegrant abilities of these starches in tablet formulation were studied using paracetamol as a model drug. Paracetamol tablets were formulated by wet granulation method and direct compression using NAS, AS, and EHS as binders. The tablet characteristics were evaluated using friabilitor machine, disintegration machine and dissolution apparatus. The results of this study indicates that microbial and Fungi load of NAS, AS, EHS and MS range from 1 to 30 colonies forming unit (CFC) per gram. The swelling power and solubility of the starches were found to increase with temperature and the values are higher for EHS and AS. Also the NAS have crushing strength of (4.766 + 0.152), AS (7.000 + 0.500), EHS (3.900 + 0.100) and MS (5.633 + 1.184) and are significant different at (p<0.05) while friability of NAS is (0.760 + 0.068, AS (1.060 + 0.121, EHS (0.556 + 0040) and MS (0.873 + 0.1007) and they are significant different at (p<0.05). The results of disintegration profile of the tablets indicate that EHS disintegrate faster when compared to NAS, AS and MS. The results of dissolution studies of the paracetamol tablets formulated with NAS, AS, EHS and MS at t50, t70 and t90 minutes are within range of 70%-97% which showed that the release of the drug was within acceptable range (quantity dissolved in 45 min ? 70%).

Keywords: NAS = Amura Starch (Tacca involucrate), EHS = Enzyme hydrolysed Starch, AS = Acetylate Starch, MS = Maize starch, Amylose, Amylopectin, Paracetamol tablet.