African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2243

Full Length Research Paper

Novelty-induced behavior and memory enhancing activities of aqueous and ethanol extracts of Solanum incanum Linn. fruits in mice

Akanmu A. O.
  • Akanmu A. O.
  • Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.
  • Google Scholar
Sodipo O. A.
  • Sodipo O. A.
  • Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.
  • Google Scholar
Sandabe U. K.
  • Sandabe U. K.
  • Department of Veterinary Biochemistry and Physiology, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.
  • Google Scholar
Shamaki B. U.
  • Shamaki B. U.
  • Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Maiduguri, P. M. B. 1069, Maiduguri, Nigeria.
  • Google Scholar
Balogun S. T.
  • Balogun S. T.
  • Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.
  • Google Scholar
Jubrin J.
  • Jubrin J.
  • Department of Clinical Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria.
  • Google Scholar


  •  Received: 27 November 2020
  •  Accepted: 11 January 2021
  •  Published: 28 February 2021

References

Achliya G, Barbade U, Wadodkar S, Dorle A (2004). Effect of Brahmi Ghrita, a polyherbal formulation on learning and memory paradigms in experimental animals. Indian Journal of Pharmacology 36(3):159-162.

 

Adebiyi OE, Olopade FE, Olopade JO, Olayemi FO (2016). Behavioural studies on the ethanol leaf extract of Grewia carpinifolia in Wistar rats. African Health Sciences 16(1):339-346.
Crossref

 

Aderibigbe AO, Adeyemi IO, Agboola OI (2010). Central nervous system depressant properties of Treculia africana Decne. Ethnobotanical Leaflets 14(2):108-119.

 

Agrawal R, Tyagi E, Saxena G, Nath C (2009). Cholinergic influence on memory stages: a study on scopolamine amnesic mice. Indian Journal of Pharmacology 41(4):192-196.
Crossref

 

Ajayi AA, Ukponmwan OE, (1994). Possible evidence of angiotensin II and endogenous opioid modulation of novelty-induced rearing in the rat. African Journal of Medical and Medical Sciences 23(3):287-290.

 

Akinyemi AJ, Oboh G, Oyeleye SI, Ogunsuyi O (2017). Anti‐amnestic effect of curcumin in combination with donepezil, an anticholinesterase drug: Involvement of cholinergic system. Neurotoxicity Research 31(4):560-569.
Crossref

 

Anand R, Gill KD, Mahdi AA (2014). Therapeutics of Alzheimer's disease: past, present and future. Neuropharmacology 76:24.
Crossref

 

Asadbegi M, Yaghmaei P, Salehi I, Komaki A, Ebrahim-Habibi A (2017). Investigation of thymol effect on learning and memory impairment induced by intrahippocampal injection of amyloid beta peptide in high fat diet-fed rats. Metabolic Brain Disease 32(3):827-839.
Crossref

 

Asi S, Farhadi H, Naghdi N, Choopani S, Samzadeh-Kermani A, Mehdizadeh M (2011). Non-acute effects of different doses of 3, 4- methylenedioxymethamphetamine on spatial memory in the Morris water maze in Sprague-Dawley male rats. Neural Regeneration Research 6(22):1715-1719.

 

Azizi-Malekabadi H, Hosseini M, Soukhtanloo M, Sadeghian R, Fereidoni M, Khodabandehloo F (2012). Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Shamoperated rats. Arquivos De NeuroPsiquiatria 70(6):447-452.
Crossref

 

Bandar H, Hijazi A, Rammal H, Hachem A, Saad Z, Badran B. (2013). Techniques for the extraction of bioactive compounds from Lebanese Urtica dioica. American Journal of Phytomedicine and Clinical Therapeutics 1(6):507-513.

 

Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G (2010). Nootropic activity of Celastrus paniculatus seed. Pharmaceutical Biology 48(3):324-332.
Crossref

 

Chintawar SD, Somani RS, Veena S, Kasture SB (2002). Nootropic activity of Albizzia lebbeck in mice. Journal of Ethnopharmacology 81(3):299-305.
Crossref

 

CIOMS, ICLAS (2012). Council for International Organization of Medical Sciences and the International Council for Laboratory Animal Science. 

 

Cornwell BR, Baas JM, Johnson L, Holroyd T, Carver FW, Lissek S, Grillon C (2007). Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography. Neuroimage 37(1):282-289.
Crossref

 

Crawley JN (1985). Exploratory behaviour models of anxiety in mice. Neuroscience and Biobehavioural Reviews 9(1):37-44.
Crossref

 

D'Hooge R, De Deyn PP (2001). Applications of the Morris water maze in the study of learning and memory. Brain Research Reviews 36(1):60-90.
Crossref

 

Dhingra D, Parle M, Kulkarni SK (2004). Memory enhancing activity of Glycyrrhiza glabra in mice. Journal of Ethnopharmacology 91(2-3):361-365.
Crossref

 

Doukkali Z, Kamal R, Jemeli ME, Nadjmouddine M, Zellou A, Cherrah Y, Alaoui K, Taghzouti K (2016). Anti-anxiety effects of Mercurialis annua aqueous extract in the elevated plus maze test. Pharmaceutical Bioprocessing 4(4):56-61.

 

Duong S, Patel T, Chang F (2017). Dementia: What pharmacists need to know. Canadian pharmacists Journal 150(2):118-129.
Crossref

 

Elufioye TO, Oladele AT, Cyril-Olutayo CM, Agbedahunsi JM, Adesanya SA (2012). Ethnomedicinal study and screening of plants used for memory enhancement and antiaging in Sagamu, Nigeria. European Journal of Medicinal Plants 2(3):262-275.
Crossref

 

Etindele Sosso FA, Nakamura O, Nakamura M (2017). Epidemiology of Alzheimer's Disease: Comparison between Africa and South America. Journal of Neurology and Neurosciences 8(4):1-3.

 

Eysenck MW, Derakshan N, Santos R, Calvo MG (2007). Anxiety and cognitive performance: attentional control theory. Emotion 7(2):336-353Grillon, C. (2002). Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology. Biology Psychiatry 52(10):958-975.
Crossref

 

GraphPad Prism (2007). GraphPad Software Inc., San Diego CA,

View

 

Gray JR (2001). Emotional modulation of cognitive control: approach- withdrawal states double-dissociate spatial from verbal two-back task performance. Journal of Experimental Psychology General 130(3):436-452.
Crossref

 

Grupe DW, Nitschke JB (2013). Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective. Nature Reviews Neuroscience 14(7):488-501.
Crossref

 

Habtamu A, Tamene G, Adane H (2014). Phytochemical investigation on the roots of Solanum incanum, Hadiya zone. Ethiopia Journal of Medicinal Plants Studies 2(2):83-93.

 

Heo HJ, Park YJ, Suh YM, Choi SJ, Kim MJ, Cho HY, Chang YJ, Hong B, Kim HK, Kim E, Kim CJ, Kim BG, Shin DH (2003). Effects of oleamide on choline acetyltransferase and cognitive activities. Bioscience Biotechnology and Biochemistry 67(6):1284-1291.
Crossref

 

Hogas M, Ciobica A, Hogas S, Bild V, Hritcu L (2011). The effects of the administration of two different doses of manganese on short- term spatial memory and anxiety like behaviour in rats. Archives of Biological Sciences Belgrade 63(4):1031-1036.
Crossref

 

Huskisson E, Maggini S, Ruf M (2007). The influence of micronutrients on cognitive function and performance. The Journal of International Medical Research 35:1-9.
Crossref

 

Itoh J, Nabeshima T, Kameyama T (1990). Utility of an elevated plus maze for the evaluation of nootropics, scopolamine and electroconvulsive shock. Psychopharmacology 101:27-33.
Crossref

 

Jianjun G, Yoshinori I, Xuan L, Norihiro K, Wei T (2013). Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer's disease. Drug Discoveries and Therapeutics 7(2):46-57.

 

Jivad N, Rabiei Z (2014). A review study on medicinal plants used in the treatment of learning and memory impairments. Asian Pacific Journal of Tropical Biomedicine 4(10):780-789.
Crossref

 

Joshi A, Megeri K (2008). Antiamnesic evaluation of C. phlomidis Linn. bark extract in mice. Revista Brasileira de Ciências Farmacêuticas 44(4):717-725.
Crossref

 

Ju Y, Chakravarty H, Tam KY (2020). An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. ACS Chemical Neuroscience11(20):3346-3357
Crossref

 

Kelly BJ, Knopman DS (2008). Alternative medicine and Alzheimer's disease. Neurologist 14(5):299-306.
Crossref

 

Krebs-Kraft DL, Rauw G, Baker GB, Parent MB (2009). Zero net flux estimates of septal extracellular glucose levels and the effects of glucose on septal extracellular GABA levels. European journal of pharmacology 611(1-3):44-52.
Crossref

 

Kumar A, Singh A, Aggarwal A (2017). Therapeutic potentials of herbal drugs for Alzheimer's disease-an overview. Indian Journal of Experimental Biology 55(2):63-73.

 

Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG (2010). Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and antioxidative activities in mice. European Journal of Pharmacology 649 (1-3):210-217.
Crossref

 

Leggio GM, Micale V, Le Foll B, Mazzola C, Nobrega JN, Drago F (2011). Dopamine D3 receptor knock-out mice exhibit increased behavioral sensitivity to the anxiolytic drug diazepam. Journal of European College of Neuropsychopharmacology 21(4):325-332.
Crossref

 

Luck SJ, Vogel EK (2013). Visual working memory capacity: from psychophysics and neurobiology to individual differences. Trends in Cognitive Science 17(8):391-400.
Crossref

 

Maloney EA, Sattizahn JR, Beilock SL (2014). Anxiety and cognition. Wiley Interdisciplinary Reviews Cognitive Science 5(4):403-411.
Crossref

 

Mamiya T, Asanuma T, Kise M, Ito Y, Mizukuchi A, Aoto H, Ukai M (2004). Effects of Pre-germinated Brown Rice on β-Amyloid Protein-induced learning and memory deficits in mice. Biological and Pharmaceutical Bulletin 27(7):1041-1045.
Crossref

 

Milind P, Dinesh D, Kulkarni SK (2004). Memory-Strengthening Activity of Glycyrrhiza glabra in Exteroceptive and Interoceptive Behavioral Models. Journal of Medicinal Food 7(4):462-466
Crossref

 

Moran TP (2016). Anxiety and working memory capacity: a meta-analysis and narrative review. Psychological Bulletin 142(8):831-864.
Crossref

 

Mutiu YA, Abidemi JA (2013). Anxiolytic and sedative properties of hydroethanolic extract of Telfairia occidentalis leaves in mice. Revista Brasileira de Farmacognosia 23(2):301-309.
Crossref

 

Nasri S, Roghani M, Baluchnejadmojarad T, Balvardi M, Rabani T. (2012). Chronic cyanidin-3-glucoside administration improves short-term spatial recognition memory but not passive avoidance learning and memory in streptozotocin-diabetic rats. Phytotherapy Research 26(8):1205-1210.
Crossref

 

Oladele AT, Cyril -Olutayo CM, Elufioye TO (2012). Ethnobotanical survey of plants used as memory enhancer and antiaging in Ondo State, Nigeria. International Journal of Pharmaceutics 2(1):26-32.

 

Olatunji PB, Fasola RT, Onasanwo SA (2016). Ethnobotanical survey of plants used as memory enhancer in three states of Southwestern Nigeria. Journal of Applied Pharmaceutical Science 6(9):209-214.
Crossref

 

Onigbogi O, Ajayi AA, Ukponmwan OE (2000). Mechanisms of chloroquine- induced body scratching behaviour in rats: evidence of involvement of endogenous opioid peptides. Pharmacology and Biochemistry Behaviour 65(2):333-337.
Crossref

 

Opeyemi BO, Adedayo OA, Ganiyu O, Sunday IO, Abayomi FD (2018). Green leafy vegetables from two Solanum spp. (L and L) ameliorate scopolamine-induced cognitive and neurochemical impairments in rats. Food Science Nutrition 6(4):860-870.
Crossref

 

Ortega RM, Requejo AM, Andres P, LopezSobaler A, Quintas ME, Redondo MR, Navia B, Rivas T (1997). Dietary intake and cognitive function in a group of elderly people. American Journal of Clinical Nutrition 66(4):803-809.
Crossref

 

Owens M, Stevenson J, Hadwin JA, Norgate R (2012). Anxiety and depression in academic performance: an exploration of the mediating factors of worry and working memory. School Psychology International 33(4):433-449.
Crossref

 

Pahuja M, Mehla J, Reeta KH, Joshi S, Gupta YK (2012). Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals. Epilepsy Research 98:2-3.
Crossref

 

Parle M, Dhingra D (2003). Ascorbic acid: a promising memory enhancer in mice. Journal of Pharmacological Science 9(3):129-135.
Crossref

 

Piechal A, Blecharz-Klin K, JPyrzanowska J, Widy-Tyszkiewicz E (2016). Influence of long-term zinc administration on spatial learning and exploratory activity in rats. Biological Trace Element Research 172(2):408-418.
Crossref

 

Rang HP, Dale MM, Ritter JM (2001). Pharmacology, 4th ed. (USA ed.); New York, Churchill Livingstone pp. 491-665.

 

Rubio J, Dang H, Gong M, Liu X, Chen SL, Gonzales GF (2017). Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine‐induced memory impairment in mice. Food and Chemical Toxicology 45(10):1882-1890.
Crossref

 

Sandi C (2013). Stress and cognition. Wiley Interdisciplinary Reviews Cognitive Science 4(3):245-261.
Crossref

 

Sarter M, Bodewitz G, Stephens DN (1988). Attenuation of scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and beta-carbolines. Psychopharmacology 94(4):491-495.
Crossref

 

Shi J, Liu Q, Wang Y, Luo G (2010). Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. Pharmacology Biochemistry and Behaviour 96(4):449-453.
Crossref

 

Storbeck J (2012). Performance costs when emotion tunes inappropriate cognitive abilities: implications for mental resources and behavior. Journal of Experimental Psychology General 141(3):411-416.
Crossref

 

Suarez M, Perassi N, Dal Zotto S (1996). Adrenocortical response to open-field test in rats with anterodorsal thalami nuclei lesion. Archives Physiology Biochemistry 104(1):81-86.
Crossref

 

Vogel HG (2002). Drug Discovery and Evaluation. Springer - Verlag 2nd edn. Berlin Herdelberg, Germany pp. 385- 591.
Crossref

 

Zarrinkalam E, Heidarianpour A, Salehi I, Ranjbar K, Komaki A (2016). Effects of endurance, resistance and concurrent exercise on learning and memory after morphine withdrawal in rats. Life Sciences 157:19-24.
Crossref