African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Assessment of the immunomodulatory activity of Artavol® aqueous extract in Plasmodium berghei infected mice

Martin Amanya
  • Martin Amanya
  • Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, Uganda.
  • Google Scholar
Clement Olusoji Ajayi
  • Clement Olusoji Ajayi
  • Pharm-Biotechnology and Traditional Medicine Centre, Mbarara University of Science and Technology, Mbarara, Uganda.
  • Google Scholar
Bernard Natukunda
  • Bernard Natukunda
  • Department of Medical Laboratory Sciences, Mbarara University of Science and Technology, Mbarara, Uganda.
  • Google Scholar
Francis Wasswa
  • Francis Wasswa
  • Department of Immunology and Molecular Biology, Makerere University, College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
  • Google Scholar
Alice Bayiyana
  • Alice Bayiyana
  • Department of Immunology and Molecular Biology, Makerere University, College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
  • Google Scholar
Rose Nabatanzi
  • Rose Nabatanzi
  • Department of Immunology and Molecular Biology, Makerere University, College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
  • Google Scholar
Obondo Sande
  • Obondo Sande
  • Department of Immunology and Molecular Biology, Makerere University, College of Health Sciences, P. O. Box 7072, Kampala, Uganda.
  • Google Scholar
Amon Agaba
  • Amon Agaba
  • Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, Uganda.
  • Google Scholar


  •  Received: 14 March 2022
  •  Accepted: 17 May 2022
  •  Published: 31 May 2022

References

Afolayan FI, Adegbolagun O, Mwikwabe NN, Orwa J, Anumudu CJSA (2020). Cytokine modulation during malaria infections by some medicinal plants. Scientific African 8:e00428.
Crossref

 

Ajayi CO, Elujoba AA, Okella H, Oloro J, Raymond A, Weisheit A, Tolo CU, Ogwang PE (2020). In vivo antimalarial activities of five Ugandan medicinal plants on Plasmodium berghei in mice. 
Crossref

 
 

Bedi O, Krishan P (2020). Investigations on acute oral toxicity studies of purpurin by application of OECD guideline 423 in rodents. Naunyn-Schmiedeberg's Archives of Pharmacology 393(4):565-571
Crossref

 
 

Brindha PJIJOGP (2016). Role of phytochemicals as immunomodulatory agents: A review. International Journal of Green Pharmacy 10(1). 

 
 

Chinsembu KCJAT (2015). Plants as antimalarial agents in Sub-Saharan Africa. Acta Tropica 152:32-48.
Crossref

 
 

Chua CLL, Brown G , Hamilton JA, Rogerson S, Boeuf PJTIP (2013). Monocytes and macrophages in malaria: protection or pathology? 29(1):26-34..
Crossref

 
 

Dobbs KR, Crabtree JN, Dent AEJIR (2020). Innate immunity to malaria-the role of monocytes. Immunology Review 293(1):8-24.. 
Crossref

 
 

Ekor MJFIP (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Neurology 4:177.
Crossref

 
 

Greenwood BJMJ (2010). Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areas. Malaria Journal 9(3):1-7.
Crossref

 
 

Grudzien M, Rapak AJJOIR (2018). Effect of natural compounds on NK cell activation. Journal of Immunology Research.
Crossref

 
 

Kamau LW (2022). Anti-plasmodial and Immunomodulatory Effects of Combined Ajuga remota and Caesalpinia volkensii Leaf Extracts during Malaria Infection in Balb/c Mice. Doctoral dissertation, JKUAT-COHES. 

 
 

Konkel JE, Frommer F, Leech MD, Yagita H, Waisman A, Anderton SMJI (2010). PD?1 signalling in CD4+ T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide?induced tolerance. Immunology 130(1):92-102.
Crossref

 
 

Kurup SP, Butler NS, Harty JTJNRI (2019). T cell-mediated immunity to malaria. Nature Reviews Immunology 19(7):457-471..
Crossref

 
 

Lorke DJAOT (1983). A new approach to practical acute toxicity testing. Archives of Toxicology 54(4):275-287..
Crossref

 
 

Loue S (2020). Animal Experimentation in Biomedical Science. In Case Studies in Society, Religion, and Bioethics (pp. 209-228). Springer, Cham.
Crossref

 
 

Mavondo GA, Mkhwanazi BN, Mzingwane ML, Dangarembizi R, Zambuko B, Moyo O, Musiwaro P, Chikuse FF, Rakabopa C, Mpofu T (2019). Malarial inflammation-driven pathophysiology and its attenuation by triterpene phytotherapeutics. Parasitology and Microbiology Research. IntechOpen. 10.5772/intechopen.88731.

 
 

Mesa LE, Vasquez D, Lutgen P, Vélez ID, Restrepo AM, Ortiz I, Robledo SMJRDSBDMT (2017). In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans. Revista da Sociedade Brasileira de Medicina Tropical 50:52-60.
Crossref

 
 

Ogwang PE, Ogwal JO, Kasasa S, Ejobi F, Kabasa D, Obua C (2011). Use of Artemisia annua L. infusion for malaria prevention: mode of action and benefits in a Ugandan community. British Journal of Pharmaceutical Research 1(4):124.
Crossref

 
 

Ortega-Pajares A, Rogerson SJJFII (2018). The rough guide to monocytes in malaria infection. Frontiers in Immunology.
Crossref

 
 

PRISM G (2018). 8.0. 2.

View

 
 

Schlagenhauf P, Wilson ME, Petersen E, Mccarthy A, Chen LH (2019). Malaria chemoprophylaxis. Travel medicine. Elsevier.
Crossref

 
 

Shellvarajah M, Hatz C, Schlagenhauf PJTM, Disease I (2017). Malaria prevention recommendations for risk groups visiting sub-Saharan Africa: a survey of European expert opinion and international recommendations. Travel Medicine and Infectious Disease 19:49-55.
Crossref

 
 

Sodagari HR, Aryan Z, Abdolghaffari AH, Rezaei N, Sahebkar AJJOP (2018). Immunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (IBD)-Turning Strong Rationale into Strong Evidence? 21(4):294-295.
Crossref

 
 

Tizifa TA, Kabaghe AN, Mccann RS, Van Den Berg H, Van Vugt M, Phiri KSJCTMR (2018). Prevention efforts for malaria. Current Tropical Medicine Reports 5(1):41-50.
Crossref

 
 

Trottier H, Elliott SJJCJOPH (2021). World Health Organization recommends first malaria vaccine. Canadian Journal of Public Health 112(6):967-969.
Crossref

 
 

Tugume P, Kakudidi EK, Buyinza M, Namaalwa J, Kamatenesi M, Mucunguzi P, Kalema JJJOE (2016). Ethnobotanical survey of medicinal plant species used by communities around Mabira Central Forest Reserve, Uganda. 12(1):1-28.
Crossref

 
 

Willcox M, BODEKER GJB (2004). Traditional herbal medicines for malaria. Bmj 329(7475):1156-1159.
Crossref

 
 

World Health Organization (2015). Global technical strategy for malaria 2016-2030, World Health Organization.